Cancer susceptibility

Influence of the c.1517G>C genetic variant in the XRCC1 gene on pancreatic cancer susceptibility in a Chinese population

Z. M. Zhao, Li, C. G., Hu, M. G., Gao, Y. X., and Liu, R., Influence of the c.1517G>C genetic variant in the XRCC1 gene on pancreatic cancer susceptibility in a Chinese population, vol. 13, pp. 4466-4472, 2014.

We investigated the influence of the c.1517G>C genetic variant in the X-ray repair complementing group 1 gene (XRCC1) on pancreatic cancer (PC) susceptibility in Chinese patients. A total of 390 PC patients and 392 controls were enrolled in this case-control study. The genotypes of c.1517G>C genetic variants were determined using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. Our findings suggested that the allele and genotype frequencies in PC patients were significantly different from those in cancer-free controls.

Association of c.461G>A genetic variant of OGG1 gene with pancreatic cancer susceptibility in Chinese

Z. M. Zhao, Li, C. G., Hu, M. G., Zhao, G. D., and Liu, R., Association of c.461G>A genetic variant of OGG1 gene with pancreatic cancer susceptibility in Chinese, vol. 13, pp. 7256-7261, 2014.

This study aimed to evaluate the potential association of single nucleotide polymorphisms of the 8-oxoguanine DNA glycosylase gene (OGG1) with susceptibility to pancreatic cancer (PC). A total of 764 Chinese Han subjects were recruited in this study. The polymerase chain reaction-restriction fragment length polymorphism and DNA sequencing methods were used to detect the genotype of c.461G>A genetic variant of OGG1. The genotype and allele frequencies were statistically different in PC patients compared with cancer-free controls.

Subscribe to Cancer susceptibility