Cardiac function

N-ethylmaleimide-sensitive factor siRNA improves cardiac function following myocardial infarction in rats

Y. Zhou, Liu, Y., Yang, S. X., and Wang, Z., N-ethylmaleimide-sensitive factor siRNA improves cardiac function following myocardial infarction in rats, vol. 14, pp. 9478-9485, 2015.

This study examined the effects of N-ethylmaleimide-sensitive factor (NSF) small interfering RNA (siRNA) on cardiac function following myocardial infarction (MI) in rats. Thirty-six adult Sprague Dawley rats were randomly divided into three equivalent groups. An acute MI model was established by ligating the anterior descending branch of the left coronary artery and confirmed by electrocardiogram. Recombinant NSF-siRNA adenovirus (experimental), negative adenovirus (control), and normal saline were injected near the infarcted area of the left ventricle in each respective group.

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