κ-Casein polymorphism

A new tetra-primer ARMS-PCR for genotyping bovine kappa-casein polymorphisms

P. A. S. Fonseca, Rosse, I. C., DeMiranda, M., Machado, M. A., Verneque, R. S., Peixoto, M. G. C. D., and Carvalho, M. R. S., A new tetra-primer ARMS-PCR for genotyping bovine kappa-casein polymorphisms, vol. 12, pp. 6521-6526, 2013.

Kappa-casein (κ-casein) is one of the most abundant milk proteins. Its main function is to avoid the aggregation of casein micelles, keeping them, and therefore calcium phosphate, in pockets in solution. In bovines, a κ-casein functional polymorphism has been associated with fat, calcium, and protein milk contents and faster curd contraction in cheese production. Quicker curd contraction reduces the loss of milk solids, enhancing cheese yield. This polymorphism induces a double amino acid substitution (Thr136Ile and Ala148Asp).

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