CD14

Identification of CD14 transcript in blood polymorphonuclear neutrophil leukocytes and functional variation in Holsteins

J. M. Huang, Wang, X. G., Jiang, Q., Sun, Y., Yang, C. H., Ju, Z. H., Hao, H. S., Wang, C. F., Zhong, J. F., Zhu, H. B., Huang, J. M., Wang, X. G., Jiang, Q., Sun, Y., Yang, C. H., Ju, Z. H., Hao, H. S., Wang, C. F., Zhong, J. F., Zhu, H. B., Huang, J. M., Wang, X. G., Jiang, Q., Sun, Y., Yang, C. H., Ju, Z. H., Hao, H. S., Wang, C. F., Zhong, J. F., and Zhu, H. B., “Identification of CD14 transcript in blood polymorphonuclear neutrophil leukocytes and functional variation in Holsteins”, vol. 15, p. -, 2016.

Polymorphonuclear neutrophil (PMN) leukocytes are primary phagocytic cells of the bovine mammary gland and a first line of defense against invading pathogens during bovine mastitis infection. Cluster of differentiation 14 (CD14) is mainly expressed in macrophages and neutrophils and acts as a co-receptor that binds bacterial lipopolysaccharide (LPS) and recruits PMNs to CD14-LPS complexes in mammary epithelial cells.

Association of CD14 C159T polymorphism with atopic asthma susceptibility in children from Southeastern China: a case-control study

Y. N. Zhang, Li, Y. J., Li, H., Zhou, H., and Shao, X. J., “Association of CD14 C159T polymorphism with atopic asthma susceptibility in children from Southeastern China: a case-control study”, vol. 14, pp. 4311-4317, 2015.

CD14 is involved in primary immune and inflammatory responses. The -159 C/T variation in the CD14 gene plays an important role in regulating CD14 expression and has been associated with the susceptibility to various diseases, including allergies. In this study, we examined the association between the C-159T polymorphism and atopic asthma susceptibility in children from Southeastern China. The study population included 746 unrelated children of Chinese Han nationality (362 patients with atopic asthma and 384 healthy controls).

Association between polymorphisms in ADAM33, CD14, and TLR4 with asthma in the Uygur population in China

J. Wang, Simayi, M., Wushouer, Q., Xia, Y., He, Y., Yan, F., Zhang, J., Cui, S., and Wen, H., “Association between polymorphisms in ADAM33, CD14, and TLR4 with asthma in the Uygur population in China”, vol. 13, pp. 4680-4690, 2014.

We evaluated the associations between single nucleotide polymorphisms (SNPs) and haplotypes of the genes encoding a disintegrin and metalloproteinase 33 (ADAM33), cluster of differentiation 14 (CD14), and Toll-like receptor 4 (TLR4) and the susceptibility of developing specific adult phenotypes of bronchial asthma in a Chinese Uygur population.

Association of CD14 G(-1145)A and C(-159)T polymorphisms with reduced risk for tuberculosis in a Chinese Han population

M. Y. Zhao, Xue, Y., Zhao, Z. Q., Li, F. J., Fan, D. P., Wei, L. L., Sun, X. J., Zhang, X., Wang, X. C., Zhang, Y. X., and Li, J. C., “Association of CD14 G(-1145)A and C(-159)T polymorphisms with reduced risk for tuberculosis in a Chinese Han population”, vol. 11, pp. 3425-3431, 2012.

Although the role of CD14 in mediating signals from Toll-like receptors to recognize Mycobacterium tuberculosis is known, how polymorphisms in this gene affect the susceptibility to develop tuberculosis are still not clear. We examined whether single nucleotide polymorphisms at positions -1145 and -159 in the promoter region of the CD14 gene are associated with tuberculosis in a Chinese Han population in a case-control study of 432 Chinese patients with tuberculosis and 404 ethnically matched healthy controls.

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