Cell apoptosis

Expression profiles of the apoptosis signaling pathway mediated by death receptor and endoplasmic reticulum in rat liver regeneration

X. K. Xing, Li, M. H., Zhu, X. S., Xu, C. S., Xing, X. K., Li, M. H., Zhu, X. S., and Xu, C. S., Expression profiles of the apoptosis signaling pathway mediated by death receptor and endoplasmic reticulum in rat liver regeneration, vol. 15, p. -, 2016.

The death receptor and endoplasmic reticulum (ER) are closely related to cell apoptosis, and it is worth studying whether the apoptosis pathways mediated by them are involved in liver regeneration. To understand the mechanism underlying death receptor- and ER-mediated apoptosis during rat liver regeneration, we used the Rat Genome 230 2.0 Array to determine the changes in gene expression. We then searched the gene ontology (GO) and NCBI databases for genes associated with cell apoptosis mediated by the death receptor and ER.

Protective effect of necrostatin-1 on myocardial tissue in rats with acute myocardial infarction

Y. R. Liu, Xu, H. M., Liu, Y. R., and Xu, H. M., Protective effect of necrostatin-1 on myocardial tissue in rats with acute myocardial infarction, vol. 15, p. -, 2016.

The aim of this study was to investigate the protective effect of necrostatin-1 on myocardial tissue of acute myocardial infarction (AMI) rats and to provide a basis for necrostatin-1 for the treatment of acute myocardial infarction. AMI rats (45) were established by ligating the anterior descending branch of the left coronary artery. The rats were randomly divided into the model group and necrostatin-1 low-dose and high-dose groups. The control group rats (15) underwent the sham operation.

Effects of lentiviral short hairpin RNA silencing of Toll-like receptor 4 on the lens epithelial cell line HLEC

H. T. Yu, Lu, P. R., Yu, H. T., and Lu, P. R., Effects of lentiviral short hairpin RNA silencing of Toll-like receptor 4 on the lens epithelial cell line HLEC, vol. 15, p. -, 2016.

The aim of this study was to observe the proliferation of, and cell-cycle changes in, the human lens epithelial cell line HLEC after Toll-like receptor 4 (TLR4) gene silencing. HLEC cells were transfected with four TLR4-short hairpin RNA (shRNA) lentiviral vectors or the control lentivirus (pGCL-GFP-shRP-1, -2, -3, -4, NC). TLR4 silencing was verified in these cells 96 h post-transfection using real-time polymerase chain reaction and western blot.

Expression of miR-98 in myocarditis and its influence on transcription of the FAS/FASL gene pair

B. Y. Zhang, Zhao, Z., Jin, Z., Zhang, B. Y., Zhao, Z., and Jin, Z., Expression of miR-98 in myocarditis and its influence on transcription of the FAS/FASL gene pair, vol. 15, p. -, 2016.

Myocarditis is a common cardiovascular disease and frequently occurs in children and teenagers. It is believed to be caused by both endogenous and exogenous factors, among which FAS/FASL gene pair-induced cell apoptosis is a major mechanism of myocardial cell injury. A previous study has detected low expression of microRNA (miR)-98 in myocarditis patients. Therefore, in this study we investigated the functional implications of miR-98 with respect to the disease. We carried out a case-control study including 50 myocarditis patients and 50 healthy individuals.

Effect of uric acid on mitochondrial function and oxidative stress in hepatocytes

Y. Yang, Zhou, Y., Cheng, S., Sun, J. L., Yao, H., Ma, L., Yang, Y., Zhou, Y., Cheng, S., Sun, J. L., Yao, H., and Ma, L., Effect of uric acid on mitochondrial function and oxidative stress in hepatocytes, vol. 15, p. -, 2016.

Here, we investigated the effect of uric acid (UA) on hepatocyte mitochondria. Hepatocytes cultured in vitro were treated with varying concentrations of UA. The change in apoptotic activity was detected by flow cytometry. The DNA damage index 8-hydroxy-deoxy-guanosine (8-OHdG) and mitochondrial function indices succinate dehydrogenase (SDH), cytochrome C oxidase (CCO), and adenosine triphosphate (ATP) were detected by enzyme assays. Reactive oxygen species (ROS) accumulation was confirmed by a dichloro-dihydro-fluorescein diacetate assay.

Effect of cyclosporin A particles of varying diameters on gastric cancer cell apoptosis

X. L. Xing, Lu, Y., Qiu, H. L., Xing, X. L., Lu, Y., Qiu, H. L., Xing, X. L., Lu, Y., and Qiu, H. L., Effect of cyclosporin A particles of varying diameters on gastric cancer cell apoptosis, vol. 15, p. -, 2016.

Human health is significantly threatened by gastric cancer, which is the most common malignant tumor; although drastic, surgery is currently the only way to cure it. However, high recurrence rates and low survival rates are associated with the disease. Therefore, to improve the effectiveness of gastric cancer treatment and to increase the clinical cure rate, we investigated the effect of cyclosporin A particles of varying diameter on gastric cancer cell apoptosis.

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