Cell cycle

Target fishing of glycopentalone using integrated inverse docking and reverse pharmacophore mapping approach

A. B. Gurung, Ali, M. A., Bhattacharjee, A., Al-Anazi, K. M., Farah, M. A., Al-Hemaid, F. M., Abou-Tarboush, F. M., Lee, J., Kim, S. Y., Al-Anazi, F. S. M., Gurung, A. B., Ali, M. A., Bhattacharjee, A., Al-Anazi, K. M., Farah, M. A., Al-Hemaid, F. M., Abou-Tarboush, F. M., Lee, J., Kim, S. Y., and Al-Anazi, F. S. M., Target fishing of glycopentalone using integrated inverse docking and reverse pharmacophore mapping approach, vol. 15, p. -, 2016.

Glycopentalone isolated from Glycosmis pentaphylla (family Rutaceae) has cytotoxic and apoptosis inducing effects in various human cancer cell lines; however, its mode of action is not known. Therefore, target fishing of glycopentalone using a combined approach of inverse docking and reverse pharmacophore mapping approach was used to identify potential targets of glycopentalone, and gain insight into its binding modes against the selected molecular targets, viz., CDK-2, CDK-6, Topoisomerase I, Bcl-2, VEGFR-2, Telomere:G-quadruplex and Topoisomerase II.

Molecular cloning and functional characterization of cyclin E and CDK2 from Penaeus monodon

C. Zhao, Fu, M. J., Qiu, L. H., Zhao, C., Fu, M. J., and Qiu, L. H., Molecular cloning and functional characterization of cyclin E and CDK2 from Penaeus monodon, vol. 15, p. -, 2016.

Reduced reproductive performance of the black tiger shrimp (Penaeus monodon) has caused economic losses and hampered the fishing industry. Detailed investigation of the molecular mechanism by which the cell cycle is regulated in this organism is needed to understand the development and maturation of ovaries and oocytes, with a view to improving reproductive capacity. Cell cycle progression is mainly determined by cyclin-dependent kinase (CDK) and cyclin complexes, the cyclin E/CDK2 complex playing a key role in G1/S transition.

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