Chinese

Association of CD226 polymorphisms with the susceptibility to type 1 diabetes in Chinese children

J. S. Xi, Nie, C. L., Wang, J., Ma, Y., and Ma, A. H., Association of CD226 polymorphisms with the susceptibility to type 1 diabetes in Chinese children, vol. 14, pp. 15249-15255, 2015.

Polymorphisms in the CD226 gene have been reported to be associated with autoimmune diseases. The aim of our study was to investigate the association between two single nucleotide polymorphisms (SNPs) (rs763361 and rs727088) in the CD226 gene and the risk for developing type 1 diabetes (T1D) in Chinese Han children. This case-control study included a total of 152 Chinese children with T1D and 304 matched-pair, healthy controls based on age and gender.

Association of TLR2 and TLR4 non-missense single nucleotide polymorphisms with type 2 diabetes risk in a southern Chinese population: a case-control study

W. H. Huang, Nie, L. H., Zhang, L. J., Jing, L. P., Dong, F., Wang, M., Zhang, N., Liu, Y., Zhang, B. H., Chen, C., Lin, H. S., Wei, X. C., Yang, G., and Jing, C. X., Association of TLR2 and TLR4 non-missense single nucleotide polymorphisms with type 2 diabetes risk in a southern Chinese population: a case-control study, vol. 14, pp. 8694-8705, 2015.

Toll-like receptors (TLRs), the triggers of the innate and adaptive immune responses, are involved in the pathogenesis of type 2 diabetes mellitus (T2DM). Several studies have investigated the effects of genetic polymorphisms in TLR4 and TLR2, but they have yielded limited results. We investigated whether non-missense genetic polymorphisms in the regulatory regions of TLR4 and TLR2 were related to T2DM in a southern Chinese population.

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