Chinese Han population

Association of VDR polymorphisms with type 2 diabetes mellitus in Chinese Han and Hui populations

J. R. Xu, Yang, Y., Liu, X. M., and Wang, Y. J., Association of VDR polymorphisms with type 2 diabetes mellitus in Chinese Han and Hui populations, vol. 13, pp. 9588-9598, 2014.

We investigated the association between vitamin D receptor (VDR) and susceptibility to type 2 diabetes mellitus (T2DM). Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis was conducted to examine single nucleotide polymorphisms (SNPs) of the rs1544410 (BsmI, G>A), rs757343 (Tru9I, G>A), rs731236 (TaqI, T>C), and rs739837 (BglI, G>T) loci of the VDR gene in 334 healthy individuals (Hui 115, Han 219) and 355 T2DM patients (Hui 154, Han 201) living in the Ningxia Hui Autonomous Region of China.

Association of MHC class-III gene polymorphisms with ER-positive breast cancer in Chinese Han population

Q. Pan, Ning, Y., Chen, L. Z., Zhang, S., Liu, Z. Z., Yang, X. X., Wei, W., Wei, H., Li, Q. G., Yue, H. N., and Wang, J. X., Association of MHC class-III gene polymorphisms with ER-positive breast cancer in Chinese Han population, vol. 11, pp. 4299-4306, 2012.

Polymorphisms of the major histocompatibility complex (MHC) have been linked to many diseases, especially autoimmune disorders. Previous studies have shown that genetic variants in MHC class III are associated with breast cancer. To determine if there is an association between MHC class III and breast cancer risk in the Chinese Han population, we carried out a hospital-based case-control study in Guangdong and Jiangsu Provinces, including 216 histologically confirmed breast cancer patients and 216 healthy controls.

Genetic variations in MOV10 and CACNB2 are associated with hypertension in a Chinese Han population

G. L. Hong, Chen, X. Z., Liu, Y., Liu, Y. H., Fu, X., Lin, S. B., and Zhu, Q., Genetic variations in MOV10 and CACNB2 are associated with hypertension in a Chinese Han population, vol. 12, pp. 6220-6227, 2013.

Human hypertension is a complex, multifactorial disease. Multiple variants associated with hypertension have been identified in the large numbers of genome-wide association studies, meta-analysis, and case-control studies. The present study investigated the association between the single nucleotide polymorphisms (SNPs) of five candidate genes and the susceptibility and prognosis of hypertension in a Chinese Han population. A hospital-based case-control study in a Chinese Han population was carried out, including 500 hypertension patients and 506 healthy controls.

No association of polymorphisms in the suppressor of cytokine signaling (SOCS)-3 with rheumatoid arthritis in the Chinese Han population

L. P. Sun, Ma, X. L., Liu, H. X., Wang, Y. S., and Li, X. F., No association of polymorphisms in the suppressor of cytokine signaling (SOCS)-3 with rheumatoid arthritis in the Chinese Han population, vol. 9, pp. 1518-1524, 2010.

Suppressor of cytokine signaling (SOCS)-3 is a key negative regulator of cytokine signaling that inhibits the JAK/STAT signal transduction pathway; there are reports describing its role in attenuating arthritis through SOCS-3 overexpression. We examined the relationship between polymorphisms in the coding sequence and promoter region of SOCS-3 and rheumatoid arthritis (RA) in a Chinese Han population.

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