Chinese population

CYP4F2 gene single nucleotide polymorphism is associated with ischemic stroke

H. - Q. Yan, Yuan, Y., Zhang, P., Huang, Z., Chang, L., and Gui, Y. - K., CYP4F2 gene single nucleotide polymorphism is associated with ischemic stroke, vol. 14, pp. 659-664, 2015.

The objective of this study was to explore the relationship between CYP4F2 gene polymorphism and ischemic stroke (IS) in the Han Chinese population. We performed a case-control study to genotype four single nucleotide polymorphisms (SNPs) (rs2108622, rs3093100, rs3093105, rs3093135) in the CYF4F2 gene. The genotype and haplotype distributions were compared between the case and control groups. We found that the GG genotype of rs2108622 in the CYP4F2 gene was associated with risk of IS (P = 0.023).

Single-nucleotide polymorphisms in dopamine receptor D1 are associated with heroin dependence but not impulsive behavior

J. H. Liu, Zhong, H. J., Dang, J., Peng, L., and Zhu, Y. S., Single-nucleotide polymorphisms in dopamine receptor D1 are associated with heroin dependence but not impulsive behavior, vol. 14, pp. 4041-4050, 2015.

Previous studies suggested that dopamine receptors may be associated with drug dependence and impulsive behavior. In this study, we examined whether dopamine receptor D1 (DRD1) is associated with heroin dependence and the impulsive behavior in patients with heroin dependence. The participants included 367 patients with heroin dependence and 372 healthy controls from a Chinese Han population.

High methylation of the SEPT9 gene in Chinese colorectal cancer patients

X. L. Su, Wang, Y. F., Li, S. J., Zhang, F., and Cui, H. W., High methylation of the SEPT9 gene in Chinese colorectal cancer patients, vol. 13, pp. 2513-2520, 2014.

Methylation of the septin 9 gene (SEPT9) occurs in higher frequency in colorectal cancer (CRC) compared to control samples, which suggests that SEPT9 methylation is a useful biomarker for screening CRC. However, the methylation status of SEPT9 in Chinese CRC patients is scarcely reported. In the present study, SEPT9 methylation was tested in CRC tissues obtained from a Chinese population and correlations with pathological characteristics were investigated.

IL-6 gene promoter polymorphisms and risk of coronary artery disease in a Chinese population

G. Q. Sun, Wu, G. D., Meng, Y., Du, B., and Li, Y. B., IL-6 gene promoter polymorphisms and risk of coronary artery disease in a Chinese population, vol. 13, pp. 7718-7724, 2014.

We investigated the relationships between single nucleotide polymorphisms (SNPs) of the interleukin (IL)-6 gene 174 G>C (rs1800795), 572 G>C (rs1800796), and 597 G/A (rs1800797) and coronary artery disease (CAD) risk in a Chinese population. This case-control study recruited 296 CAD patients and 327 controls between January 2009 and May 2012. Genotyping of IL-6 174 G>C (rs1800795), 572 G>C (rs1800796), and 597 G/A (rs1800797) was performed on a 384-well plate format using the Sequenom MassARRAY platform.

Single nucleotide polymorphisms in the ORM1-like 3 gene associated with childhood asthma in a Chinese population

F. F. Yang, Huang, Y., Li, Q. B., Dai, J. H., and Fu, Z., Single nucleotide polymorphisms in the ORM1-like 3 gene associated with childhood asthma in a Chinese population, vol. 11, pp. 4646-4653, 2012.

Single nucleotide polymorphism (SNP)-based genome-wide association studies have revealed that polymorphisms of the ORM1-like 3 (ORMDL3) gene are associated with childhood asthma. We investigated genetic associations of SNPs in and around the ORMDL3 gene with childhood asthma in a Chinese population. Genomic DNA was extracted from peripheral venous blood drawn from 152 subjects with childhood asthma and from 190 control subjects. SNP genotyping was performed with the MassARRAY system (Sequenom) by means of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.

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