Chondral defect

Effects of intra-articular injection of mesenchymal stem cells associated with platelet-rich plasma in a rabbit model of osteoarthritis

L. C. Hermeto, DeRossi, R., Oliveira, R. J., Pesarini, J. R., Antoniolli-Silva, A. C. M. B., Jardim, P. H. A., Santana, Á. E., Deffune, E., Rinaldi, J. C., Justulin, L. A., Hermeto, L. C., DeRossi, R., Oliveira, R. J., Pesarini, J. R., Antoniolli-Silva, A. C. M. B., Jardim, P. H. A., Santana, Á. E., Deffune, E., Rinaldi, J. C., and Justulin, L. A., Effects of intra-articular injection of mesenchymal stem cells associated with platelet-rich plasma in a rabbit model of osteoarthritis, vol. 15, p. -, 2016.

The current study aims to evaluate the macroscopic and histological effects of autologous mesenchymal stem cells (MSC) and platelet-rich plasma on knee articular cartilage regeneration in an experimental model of osteoarthritis. Twenty-four rabbits were randomly divided into four groups: control group, platelet-rich plasma group, autologous MSC undifferentiated group, and autologous MSC differentiated into chondrocyte group. Collagenase solution was used to induce osteoarthritis, and treatments were applied to each group at 6 weeks following osteoarthritis induction.

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