Circulation

Circulatory microRNA-145 expression is increased in cerebral ischemia

C. S. Gan, Wang, C. W., and Tan, K. S., Circulatory microRNA-145 expression is increased in cerebral ischemia, vol. 11. pp. 147-152, 2012.

Cerebral ischemia or ischemic stroke is mainly attributed to vascular and circulation disorders. Among protein biomarkers, RNA profiles have also been identified as markers of ischemic stroke. MicroRNA-145 expression is ostensibly recognized as marker and modulator of vascular smooth muscle cell phenotype; however, expression levels in ischemic stroke had not been investigated. Employing real-time quantitative PCR, we examined the expression profile of circulatory microRNA-145 in healthy control subjects (N = 14) and ischemic stroke patients (N = 32).

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