Clinical outcome

GSTP1 Ile105Val and XRCC1 Arg399Gln gene polymorphisms contribute to the clinical outcome of patients with advanced non-small cell lung cancer

L. Bu, Zhang, L. B., Mao, X., Wang, P., Bu, L., Zhang, L. B., Mao, X., and Wang, P., “GSTP1 Ile105Val and XRCC1 Arg399Gln gene polymorphisms contribute to the clinical outcome of patients with advanced non-small cell lung cancer”, vol. 15, p. -, 2016.

Glutathione S-transferase P1 (GSTP1) and X-ray repair cross-complementing group 1 (XRCC1) genetic variations may in­fluence the efficacy of chemotherapy in various cancers. We investi­gated the possible roles of GSTP1 Ile105Val and XRCC1 Arg194Trp, and Arg399Gln gene polymorphisms in the prognosis of advanced non-small cell lung carcinoma (NSCLC) patients with cisplatin-based chemotherapy.

Role of VEGF gene polymorphisms in the clinical outcome of non-small cell lung cancer

N. Chen, Ma, C. N., Zhao, M., and Zhang, Y. J., “Role of VEGF gene polymorphisms in the clinical outcome of non-small cell lung cancer”, vol. 14, pp. 16006-16011, 2015.

This report details a study conducted to assess the role of VEGF gene polymorphisms in the prognosis of advanced non-small cell lung carcinoma (NSCLC). Samples obtained from 210 advanced NSCLC patients admitted at the Huaihe Hospital of Henan University between January 2010 and December 2011 were recruited for this study. The VEGF -2578C/A (rs699947), +936C/T (rs3025039), and -634G/C (rs2010963) genotypes were analyzed by polymerase chain reaction-restriction fragment length polymorphism.

Genetic variability of ERCC1 and ERCC2 influences treatment outcomes in gastric cancer

W. H. Yu, Wang, Y. X., Guo, J. Q., Wang, Y. L., Zheng, J. S., and Zhu, K. X., “Genetic variability of ERCC1 and ERCC2 influences treatment outcomes in gastric cancer”, vol. 14, pp. 17529-17535, 2015.

We performed a study to investigate the role of ERCC1 (rs11615, rs2298881, and rs3212986) and ERCC2 (rs13181, rs238406, and rs1799793) polymorphisms in the prognosis of gastric cancer. A total of 346 patients with gastric cancer were recruited between May 2009 and May 2012. Single nucleotide polymorphism genotyping was performed using the Sequenom MassARRAY platform. The GA+AA genotype of ERCC2 rs1799793 showed significant and favorable response to chemotherapy than the wide-type GG genotype in multivariate analysis (OR = 1.78, 95%CI = 1.13-2.81).

Association between ERCC1 and ERCC2 gene polymorphisms and chemotherapy response and overall survival in osteosarcoma

Z. H. Cao, Yin, H. P., Jiang, N., and Yu, B., “Association between ERCC1 and ERCC2 gene polymorphisms and chemotherapy response and overall survival in osteosarcoma”, vol. 14, pp. 10145-10151, 2015.

We aimed to evaluate the influence of four SNPs in ERCC1 and ERCC2 on the response to cisplatin-based treatment and on clinical outcome in patients with osteosarcoma. We identified 186 patients with osteosarcoma diagnosed between April 2009 and April 2011 who were eligible for inclusion in our study. Genotyping of ERCC1 rs11615, rs3212986, and rs2298881; and ERCC2 rs1799793 and rs13181 was conducted by a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay.

Association of GSTP1 and XRCC1 gene polymorphisms with clinical outcomes of patients with advanced non-small cell lung cancer

J. Y. Liu, Li, L. R., and Liu, Q. M., “Association of GSTP1 and XRCC1 gene polymorphisms with clinical outcomes of patients with advanced non-small cell lung cancer”, vol. 14, pp. 10331-10337, 2015.

We investigated the association between the polymorphisms GSTP1 rs1695 and XRCC1 rs1799782 and rs25487 and the clinical outcome of patients with non-small cell lung cancer (NSCLC) receiving cisplatin-based chemotherapy. Genotyping of GSTP1 rs1695 and XRCC1 rs1799782, and rs25487 was conducted by polymerase chain reaction-restriction fragment length polymorphism analysis.

Effect of single nucleotide polymorphisms in the ATP-binding cassette B1 gene on the clini­cal outcome of traumatic brain injury

Z. L. Wang, Xu, D. S., Wang, Y. X., Qin, H., and Geng, D., “Effect of single nucleotide polymorphisms in the ATP-binding cassette B1 gene on the clini­cal outcome of traumatic brain injury”, vol. 14, pp. 10948-10953, 2015.

The critical role of ATP-binding cassette B1 (ABCB1) in the function of the blood-brain barrier led us to conducted this prospective study in order to investigate the clinical outcome of patients suffering from severe traumatic brain injury. A total of 182 patients with traumatic brain injury were included in our study. Genotyping of ABCB1 C3435T and G2677T/A was conducted using polymerase chain reaction-restriction fragment length polymorphism.

Glutathione S-transferase polymorphisms influence chemotherapy response and treatment outcome in breast cancer

J. Wang, Wang, T., Yin, G. - Y., Yang, L., Wang, Z. - G., and Bu, X. - B., “Glutathione S-transferase polymorphisms influence chemotherapy response and treatment outcome in breast cancer”, vol. 14, pp. 11126-11132, 2015.

The aim of this study was to evaluate the role of GSTM1 null/present, GSTT1 null/present, and GSTP1 IIe105Val polymor­phisms in the clinical response to chemotherapy and treatment outcome of patients with breast cancer. A total of 262 subjects were randomly selected from among patients with a histologically confirmed breast cancer. The genotypes of GSTM1, GSTT1, and GSTP1 IIe105Val poly­morphisms were determined by polymerase chain reaction-restriction fragment length polymorphism analysis.

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