Clinicopathological characteristics

Relationship between clinicopathological features and HIF-2α in gastric adenocarcinoma

N. Li, Wang, H. X., Qin, C., Wang, X. H., and Han, F. Y., “Relationship between clinicopathological features and HIF-2α in gastric adenocarcinoma”, vol. 14, pp. 1404-1413, 2015.

Hypoxia influences tumor growth by inducing angiogenesis and genetic alterations. Hypoxia-inducible factor-2α (HIF-2α) plays an essential role in oxygen homeostasis. Expression of HIF-2α-inducible genes is associated with tumor progression. In this study, we investigated this correlation immunohistochemically and using quantitative reverse transcription-polymerase chain reaction to examine various clinical and pathological features in 55 specimens of gastric cancer and 40 specimens of normal gastric tissue.

HIF-2α as a prognostic marker for breast cancer progression and patient survival

H. X. Wang, Qin, C., Han, F. Y., Wang, X. H., and Li, N., “HIF-2α as a prognostic marker for breast cancer progression and patient survival”, vol. 13, pp. 2817-2826, 2014.

Malignant cells show increased invasion potency in vitro and in vivo. This process is considered to be mediated by matrix-metalloproteases (MMPs). Hypoxia-inducible factor-2α (HIF-2α) may upregulate MMP-2 expression; however, little is known about the correlation between HIF-2α and MMP-2 expressions in breast cancer. The current study investigated this correlation immunohistochemically according to various clinical and pathological features in 102 paraffin-embedded archival tissue block specimens from patients with breast cancer.