Colorectal cancer

Expression changes in epithelial cell adhesion molecule during colorectal cancer tumorigenesis

X. B. Chai, Song, R. F., and Xu, F., “Expression changes in epithelial cell adhesion molecule during colorectal cancer tumorigenesis”, vol. 14, pp. 7624-7629, 2015.

We investigated the relationship between the expression of epithelial cell adhesion molecule (EpCAM) and the occurrence and development of colon cancer. Fifty colon cancer tissues and adjacent normal tissues were collected, while 40 normal intestinal mucosa tissues were collected as the blank group. EpCAM expression was detected by immunohistochemistry and the patients were followed-up to evaluate the prognosis.

Effect of ZNF217 gene polymorphisms on colorectal cancer development in a Mexican population

R. Ramírez-Ramírez, Gutierrez-Angulo, M., Magaña, M. T., Moreno-Ortiz, J. M., Partida-Pérez, M., Muñiz-Mendoza, R., Peregrina-Sandoval, J., Suárez-Villanueva, A. S., Centeno-Flores, M., Maciel-Gutiérrez, V. M., Cabrales-Vazquez, E., and Ayala-Madrigal, M. L., “Effect of ZNF217 gene polymorphisms on colorectal cancer development in a Mexican population”, vol. 14, pp. 362-367, 2015.

The ZNF217 gene, a potential oncogene amplified and overexpressed in several cancers including colorectal cancer (CRC), acts as a transcription factor that activates or represses target genes. The polymorphisms rs16998248 (T>A) and rs35720349 (C>T) in coronary artery disease have been associated with reduced expression of ZNF217. In this study, we analyzed the 2 polymorphisms in Mexican patients with CRC.

Association between ERCC1 and XPF polymorphisms and risk of colorectal cancer

H. Yang, Li, G., and Li, W. F., “Association between ERCC1 and XPF polymorphisms and risk of colorectal cancer”, vol. 14, pp. 700-705, 2015.

We conducted a hospital-based case-control study to evaluate the association between polymorphisms in excision repair cross-complementing group 1-xeroderma pigmentosum group F (ERCC1-XPF) variants and the risk of colorectal cancer in a Chinese population. Genotyping of the ERCC1 rs2298881 and rs11615 and XPF rs2276466 polymorphisms were detected by polymerase chain reaction-restriction fragment length polymorphism. Colorectal cancer cases were more likely to be smokers, consume alcohol, have higher energy intake, and have a family history of cancer.

IGFBP-3 A-202C and C2133G polymorphisms and colorectal cancer risk: a meta-analysis of case-control studies

J. Xu, Xu, L., Li, L. T., You, Q., and Cha, L. S., “IGFBP-3 A-202C and C2133G polymorphisms and colorectal cancer risk: a meta-analysis of case-control studies”, vol. 14, pp. 3370-3386, 2015.

Recent evidence suggests that genetic variations in the IGFBP-3 gene may impact susceptibility to colorectal cancer, but individually published results are inconclusive. Our meta-analysis was aimed at providing a more precise estimation of these associations. An extensive literature search was conducted for appropriate articles published before May 1, 2013. This meta-analysis was performed using the STATA 12.0 software. The crude odds ratios (OR) with 95% confidence interval (CI) were calculated.

Relationship between DNA repair gene XPD751 single-nucleotide polymorphisms and prognosis of colorectal cancer

Y. Dong, Liu, J. W., Gao, Y. J., Zhou, T., and Chen, Y. M., “Relationship between DNA repair gene XPD751 single-nucleotide polymorphisms and prognosis of colorectal cancer”, vol. 14, pp. 5390-5398, 2015.

We examined the relationships between single-nucleotide polymorphisms (SNPs) in the DNA repair gene XPD751 and the efficacy and time to disease progression (TTP) in colorectal cancer patients after platinum-based chemotherapy. Ninety-eight patients diagnosed with advanced colorectal cancer were subjected to oxaliplatin and 5-fluorouracil combination therapy. DNA was extracted from venous blood before chemotherapy. Polymerase chain reaction-restriction fragment length polymorphism analysis was used to detect XPD751 SNPs.

Effect of Rhizoma paridis total saponins on apoptosis of colorectal cancer cells and imbalance of the JAK/STAT3 molecular pathway induced by IL-6 suppression

W. - J. Teng, Chen, P., Zhu, F. - Y., Di, K., Zhou, C., Zhuang, J., Cao, X. - J., Yang, J., Deng, L. - J., and Sun, C. - G., “Effect of Rhizoma paridis total saponins on apoptosis of colorectal cancer cells and imbalance of the JAK/STAT3 molecular pathway induced by IL-6 suppression”, vol. 14, pp. 5793-5803, 2015.

We observed the influence of different concentrations of Rhizoma paridis total saponins (RPTS) on the apoptosis of colorectal cancer cells and explored the internal mechanism involved. We determined whether RPTS influences the interleukin-6 (IL-6)/Janus kinase (JAK)-signal transducer and activator of transcription-3 (STAT3) apoptosis  molecular pathway and looked for colon cancer-related signal transduction pathways or targets inducing apoptosis.

 Identification of critical TF-miRNA-mRNA regulation loops for colorectal cancer metastasis

C. Wang, Hu, D. Z., and Liu, J. Z., “ Identification of critical TF-miRNA-mRNA regulation loops for colorectal cancer metastasis”, vol. 14, pp. 5485-5495, 2015.

To explore the potential cause of colorectal cancer metastasis, gene expression profiles, GSE21510, and miRNA expression profiles, GSE48074, were downloaded from the Gene Expression Omnibus database. Differentially expressed genes in metastatic colorectal and non metastatic colorectal cancer compared with the normal samples were identified via the limma package in R. The differentially expressed miRNAs in colorectal cancer samples with lymph node metastasis compared with those without lymph node metastasis were screened out by the some method.

Predictive value of CK20 in evaluating the efficacy of treatment and prognosis after surgery for colorectal cancer

W. X. Li, Xiao, H. W., Hong, X. Q., and Niu, W. X., “Predictive value of CK20 in evaluating the efficacy of treatment and prognosis after surgery for colorectal cancer”, vol. 14, pp. 5823-5829, 2015.

Herein, correlations between expression levels of CK20 and efficacy of treatment and postoperative prognosis of colorectal cancer were evaluated to elucidate the clinical value of CK20. Postoperative follow-up was performed on 62 patients who underwent surgery for colorectal cancer between January 2010 and December 2010. Samples of tumor tissues and intraperitoneal drainage fluids were collected. Blood samples were obtained during the 2-year follow-up period.

Serum level of endothelial cell-specific molecule-1 and prognosis of colorectal cancer

H. Jiang, Fu, X. G., and Chen, Y. T., “Serum level of endothelial cell-specific molecule-1 and prognosis of colorectal cancer”, vol. 14, pp. 5519-5526, 2015.

We evaluated the clinical significance and explored the prognostic value of serum endothelial cell-specific molecule-1 (ESM-1) expression in colorectal cancer (CRC) in a Chinese population. Serum samples were obtained from 89 CRC patients undergoing surgical treatment and 90 healthy volunteers (control group). ESM-1 levels in serum samples from CRC patients and controls were measured using a sandwich enzyme-linked immunosorbent assay. Overall survival was analyzed by the log-rank test, and survival curves were plotted according to the Kaplan-Meier method.

Enhanced expression and significance of glycosylphosphatidylinositol anchor attachment protein 1 in colorectal cancer

G. Chen, Li, S. Y., Cai, H. Y., and Zuo, F. Y., “Enhanced expression and significance of glycosylphosphatidylinositol anchor attachment protein 1 in colorectal cancer”, vol. 13, pp. 499-507, 2014.

The aim of this study was to investigate the expression of glycosylphosphatidylinositol anchor attachment protein 1 (GPAA1) and its significance in patients with colorectal cancer. Fifty-two patients with primary colorectal cancer were included in this study. GPAA1 expression was detected by immunohistochemistry, reverse transcription-polymerase chain reaction, and Western blot analysis. A cell invasion assay was performed by the transwell method.

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