Colorectal cancer

Matrix metalloproteinase 9 -1562C/T polymorphism increased protein levels in patients with colorectal cancer in a sample from southeastern Brazil

C. R. Hoelzle, Magalhães, K. C. S. F., Carvalho, S. S., Santos, G. A., Maia, I. M., Sousa, M. C. P. S., Andrade-Filho, J. S., Cruz, G. M. G., Simões, R. T., Hoelzle, C. R., Magalhães, K. C. S. F., Carvalho, S. S., Santos, G. A., Maia, I. M., Sousa, M. C. P. S., Andrade-Filho, J. S., Cruz, G. M. G., Simões, R. T., Hoelzle, C. R., Magalhães, K. C. S. F., Carvalho, S. S., Santos, G. A., Maia, I. M., Sousa, M. C. P. S., Andrade-Filho, J. S., Cruz, G. M. G., and Simões, R. T., Matrix metalloproteinase 9 -1562C/T polymorphism increased protein levels in patients with colorectal cancer in a sample from southeastern Brazil, vol. 15, p. -, 2016.

We examined whether the allelic and/or genotypic profile of locus -1562C/T of the matrix metalloproteinase (MMP-9) gene influences the protein expression levels of MMP-9 in patients with colorectal cancer (CRC) compared with controls. A total of 104 patients with CRC and 84 controls were evaluated. Peripheral blood was collected from both groups and DNA extraction was performed for -1562C/T genotyping; the plasma was used for MMP-9 quantification. The CT genotype was associated with increased MMP-9 expression (P = 0.0211).

NLRP3 rs35829419 polymorphism is associated with increased susceptibility to multiple diseases in humans

Q. Zhang, Fan, H. W., Zhang, J. Z., Wang, Y. M., and Xing, H. J., NLRP3 rs35829419 polymorphism is associated with increased susceptibility to multiple diseases in humans, vol. 14, pp. 13968-13980, 2015.

Using a meta-analysis framework, we investigated the association between the NLRP3 rs35829419 polymorphism and increased susceptibility to diverse diseases in humans. Relevant published studies were identified through a comprehensive and systematic electronic search, using the following scientific literature databases: Science Citation Index, the Cochrane Library, PubMed, Embase, CINAHL, Current Contents Index, Chinese Biomedical, the Chinese Journal Full-Text, and the Weipu Journal.

Expression profile of the GA733 gene family in colorectal cancer: correlation with clinicopathological parameters

I. Mamaloudis, Zacharoulis, D., Samara, M., Papadopoulos, G., Samara, S., Koukoulis, G., Chatzitheofilou, C., and Kollia, P., Expression profile of the GA733 gene family in colorectal cancer: correlation with clinicopathological parameters, vol. 14, pp. 14772-14781, 2015.

GA733-1/-2/-3 genes have been detected in various types of cancer, although their role has not been fully clarified. GA733-2 and GA733-1 have been correlated with lymph node metastases in laryngeal cancer and liver metastases, respectively. Only a few studies have elucidated the mechanisms regulating GA733-1/-2 expression and their effect on colorectal cancer. Therefore, the expression pattern and the role of the aforementioned molecules in colorectal carcinogenesis were evaluated in this study.

Meta-analysis of the relationship between XRCC3 T241M polymorphism and colorectal cancer susceptibility

L. Z. Zhang, Li, Y. S., and Liu, H. Z., Meta-analysis of the relationship between XRCC3 T241M polymorphism and colorectal cancer susceptibility, vol. 14, pp. 14831-14839, 2015.

Numerous studies have evaluated the relationship between the T241M polymorphism of the X-ray repair cross-complementing group 3 (XRCC3) gene and colorectal cancer (CRC) risk. However, the specific relationship remains controversial. We conducted meta-analysis to investigate the relationship between the XRCC3 T241M polymorphism and CRC risk. The PubMed and Embase databases were searched for relevant studies investigating the relationship between the XRCC3 T241M polymorphism and CRC risk.

RUNX3 gene polymorphisms and haplotypes in Mexican patients with colorectal cancer

S. Suárez-Villanueva, Ayala-Madrigal, M. L., Peregrina-Sandoval, J., Macias-Gomez, N., Ramírez-Ramírez, R., Muñiz-Mendoza, R., Moreno-Ortiz, J. M., Centeno-Flores, M., Maciel-Gutiérrez, V., Cabrales, E., and Gutierrez-Angulo, M., RUNX3 gene polymorphisms and haplotypes in Mexican patients with colorectal cancer, vol. 14, pp. 15505-15510, 2015.

We analyzed a possible association between RUNX3 gene polymorphisms and haplotypes in Mexican patients with colorectal cancer (CRC). Genomic DNA samples were obtained from the peripheral blood of 176 Mexican patients with CRC at diagnosis and from 195 individuals that formed the control group. The polymorphisms were detected by polymerase chain reaction-restriction fragment length polymorphism. Association was estimated by odds ratio (OR). The haplotypes and linkage disequilibrium were established using the Arlequin v3.5 software.

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