Colorectal cancer

Matrix metalloproteinase 9 -1562C/T polymorphism increased protein levels in patients with colorectal cancer in a sample from southeastern Brazil

C. R. Hoelzle, Magalhães, K. C. S. F., Carvalho, S. S., Santos, G. A., Maia, I. M., Sousa, M. C. P. S., Andrade-Filho, J. S., Cruz, G. M. G., Simões, R. T., Hoelzle, C. R., Magalhães, K. C. S. F., Carvalho, S. S., Santos, G. A., Maia, I. M., Sousa, M. C. P. S., Andrade-Filho, J. S., Cruz, G. M. G., Simões, R. T., Hoelzle, C. R., Magalhães, K. C. S. F., Carvalho, S. S., Santos, G. A., Maia, I. M., Sousa, M. C. P. S., Andrade-Filho, J. S., Cruz, G. M. G., and Simões, R. T., Matrix metalloproteinase 9 -1562C/T polymorphism increased protein levels in patients with colorectal cancer in a sample from southeastern Brazil, vol. 15, p. -, 2016.

We examined whether the allelic and/or genotypic profile of locus -1562C/T of the matrix metalloproteinase (MMP-9) gene influences the protein expression levels of MMP-9 in patients with colorectal cancer (CRC) compared with controls. A total of 104 patients with CRC and 84 controls were evaluated. Peripheral blood was collected from both groups and DNA extraction was performed for -1562C/T genotyping; the plasma was used for MMP-9 quantification. The CT genotype was associated with increased MMP-9 expression (P = 0.0211).

NLRP3 rs35829419 polymorphism is associated with increased susceptibility to multiple diseases in humans

Q. Zhang, Fan, H. W., Zhang, J. Z., Wang, Y. M., and Xing, H. J., NLRP3 rs35829419 polymorphism is associated with increased susceptibility to multiple diseases in humans, vol. 14, pp. 13968-13980, 2015.

Using a meta-analysis framework, we investigated the association between the NLRP3 rs35829419 polymorphism and increased susceptibility to diverse diseases in humans. Relevant published studies were identified through a comprehensive and systematic electronic search, using the following scientific literature databases: Science Citation Index, the Cochrane Library, PubMed, Embase, CINAHL, Current Contents Index, Chinese Biomedical, the Chinese Journal Full-Text, and the Weipu Journal.

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