Congenital heart disease

Association of miR-196a2, miR-27a, and miR-499 polymorphisms with isolated congenital heart disease in a Chinese population

K. Yu, Ji, Y., Wang, H., Xuan, Q. K., Li, B. B., Xiao, J. J., Sun, W., and Kong, X. Q., Association of miR-196a2, miR-27a, and miR-499 polymorphisms with isolated congenital heart disease in a Chinese population, vol. 15, no. 4, p. -, 2016.

INTRODUCTION

Congenital heart disease (CHD), defined as clinically structural heart defects present before and at birth, is the leading cause of serious infant morbidity and mortality worldwide. The incidence of CHD at birth was 10-12 per 1000 live births in 2013 (Hoffman, 2013). Similarly, in China the overall incidence based on epidemiological studies was 8 per 1000 live births in 2011, an approximate increase of 6.7 times compared with 1996 (Yu et al., 2014).

Relationship between TBX20 gene polymorphism and congenital heart disease

X. F. Yang, Zhang, Y. F., Zhao, C. F., Liu, M. M., Si, J. P., Fang, Y. F., Xing, W. W., Wang, F. L., Yang, X. F., Zhang, Y. F., Zhao, C. F., Liu, M. M., Si, J. P., Fang, Y. F., Xing, W. W., and Wang, F. L., Relationship between TBX20 gene polymorphism and congenital heart disease, vol. 15, p. -, 2016.

Congenital heart disease in children is a type of birth defect. Previous studies have suggested that the transcription factor, TBX20, is involved in the occurrence and development of congenital heart disease in children; however, the specific regulatory mechanisms are yet to be evaluated. Hence, this study aimed to evaluate the relationship between the TBX20 polymorphism and the occurrence and development of congenital heart disease. The TBX20 gene sequence was obtained from the NCBI database and the polymorphic locus candidate was predicted.

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