COPD

Role and diagnostic value of gene variants in assessing the risk of chronic obstructive pulmonary disease

Z. P. Yan, Tong, X., Liu, S. T., Ma, Y., Peng, S. F., Yang, X., Fan, H., Yan, Z. P., Tong, X., Liu, S. T., Ma, Y., Peng, S. F., Yang, X., and Fan, H., Role and diagnostic value of gene variants in assessing the risk of chronic obstructive pulmonary disease, vol. 15, p. -, 2016.

Meta-analyses have revealed many positive associations between gene variants and susceptibility to chronic obstructive pulmonary disease (COPD). However, some of those positive results may be false positives. Therefore, we investigated the genetic polymorphisms associated with COPD risk and determined their diagnostic value.

MMP-9 genetic polymorphism may confer susceptibility to COPD

S. Jiang, Yang, Z. H., Chen, Y. Y., He, Z., Zhou, Y., Gao, Y., Zhang, Q., Tan, M. Q., Jiang, S., Yang, Z. H., Chen, Y. Y., He, Z., Zhou, Y., Gao, Y., Zhang, Q., Tan, M. Q., Jiang, S., Yang, Z. H., Chen, Y. Y., He, Z., Zhou, Y., Gao, Y., Zhang, Q., and Tan, M. Q., MMP-9 genetic polymorphism may confer susceptibility to COPD, vol. 15, p. -, 2016.

Correlations between genetic polymorphisms of three matrix metalloproteinase (MMP) genes and susceptibility to chronic obstructive pulmonary disease (COPD) were investigated. Relevant case-control studies were selected using rigorous inclusion and exclusion criteria. The comprehensive Meta-analysis 2.0 software was used to conduct the statistical analysis. An odds ratio with 95% confidence intervals was applied to assess the correlation between genetic polymorphisms of MMPs and susceptibility to COPD. Twelve high-quality studies were selected for inclusion in this meta-analysis.

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