COPD

MMP-9 genetic polymorphism may confer susceptibility to COPD

S. Jiang, Yang, Z. H., Chen, Y. Y., He, Z., Zhou, Y., Gao, Y., Zhang, Q., Tan, M. Q., Jiang, S., Yang, Z. H., Chen, Y. Y., He, Z., Zhou, Y., Gao, Y., Zhang, Q., Tan, M. Q., Jiang, S., Yang, Z. H., Chen, Y. Y., He, Z., Zhou, Y., Gao, Y., Zhang, Q., and Tan, M. Q., MMP-9 genetic polymorphism may confer susceptibility to COPD, vol. 15, p. -, 2016.

Correlations between genetic polymorphisms of three matrix metalloproteinase (MMP) genes and susceptibility to chronic obstructive pulmonary disease (COPD) were investigated. Relevant case-control studies were selected using rigorous inclusion and exclusion criteria. The comprehensive Meta-analysis 2.0 software was used to conduct the statistical analysis. An odds ratio with 95% confidence intervals was applied to assess the correlation between genetic polymorphisms of MMPs and susceptibility to COPD. Twelve high-quality studies were selected for inclusion in this meta-analysis.

Association between the rs3795879 G/A polymorphism of the SERPINE2 gene and chronic obstructive pulmonary disease: a meta-analysis

D. B. Tian, Cai, S. X., Pan, G. C., Zhang, Y. F., and Xiao, J. H., Association between the rs3795879 G/A polymorphism of the SERPINE2 gene and chronic obstructive pulmonary disease: a meta-analysis, vol. 14, pp. 7920-7928, 2015.

The present study aimed to investigate the effects of the rs3795879 polymorphism of the SERPINE2 gene on the development of chronic obstructive pulmonary disease (COPD) based on a systematic meta-analysis. An extensive literature search was performed to retrieve previously published case-control studies on the polymorphisms of SERPINE2 in COPD patients. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the association between SERPINE2 polymorphisms and risk of developing COPD.

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