Coronary artery disease

Identification of molecular markers in patients with hypertensive heart disease accompanied with coronary artery disease

H. Pang, Han, B., Li, Z. Y., and Fu, Q., “Identification of molecular markers in patients with hypertensive heart disease accompanied with coronary artery disease”, vol. 14, pp. 93-100, 2015.

We investigated the plasma hypersensitive C-reactive protein (hs-CRP), oxidized low-density lipoprotein (ox-LDL), and apelin levels in patients with hypertensive heart disease (HHD) plus coronary artery disease (CAD). Patients with hypertension hospitalized in Xuzhou Central Hospital were categorized into the HHD group and the HHD plus CAD group; 40 healthy subjects served as the control group. hs-CRP expression was determined with chemiluminescence. The expression of ox-LDL and apelin was analyzed with enzyme-linked immunosorbent assay.

Traditional risk factors and angiotensin-converting enzyme insertion/deletion gene polymorphism in coronary artery disease

S. Sahin, Ceyhan, K., Benli, I., Ozyurt, H., Naseri, E., Tumuklu, M. M., Aydogan, L., Elalmis, A. O., Ozugurlu, A. F., and Onalan, O., “Traditional risk factors and angiotensin-converting enzyme insertion/deletion gene polymorphism in coronary artery disease”, vol. 14, pp. 2063-2068, 2015.

We investigated whether the insertion/deletion (I/D) polymorphism in the angiotensin-converting enzyme (ACE) gene and serum ACE levels are associated with traditional risk factors of coronary artery disease (CAD). We enrolled 250 individuals without CAD and 750 individuals suffering from CAD who were angiographically diagnosed. Biochemical risk factors, the ACE (I/D) gene polymorphism, and ACE serum levels were compared. ACE genotypes were determined using real-time polymerase chain reaction.

Association between the CYP11B2 gene ˗344T>C polymorphism and coronary artery disease: a meta-analysis

Y. Liu, Liu, H. L., Han, W., Yu, S. J., and Zhang, J., “Association between the CYP11B2 gene ˗344T>C polymorphism and coronary artery disease: a meta-analysis”, vol. 14, pp. 3121-3128, 2015.

Numerous studies have evaluated the association between the CYP11B2 gene ˗344T>C polymorphism and coronary artery disease (CAD) risk. However, the specific association is still controversial. To address this issue, PubMed, EMBASE, and China National Knowledge Infrastructure databases were searched for eligible articles that reported on the relationship between the CYP11B2 gene ˗344T>C polymorphism and CAD, and were published before April 2014. Data from five separate studies with 3687 subjects were analyzed by meta-analysis.

Role of interleukin-6 gene polymorphisms in the risk of coronary artery disease

K. Wang, Dong, P. S., Zhang, H. F., Li, Z. J., Yang, X. M., and Liu, H., “Role of interleukin-6 gene polymorphisms in the risk of coronary artery disease”, vol. 14, pp. 3177-3183, 2015.

We conducted a case-control study to investigate the association between IL-6 -174 G>C and -572 C>G polymorphisms and the risk of coronary artery disease (CAD). We genotyped IL-6 ˗174 G>C and -572 C>G in 402 patients with CAD and 402 control individuals. IL-6 -174 G>C (rs1800795) and -572 C>G (rs1800796) alleles were detected by polymerase chain reaction-restriction fragment length polymorphism.

MKL1-184C>T gene polymorphism is associated with coronary artery disease in the Chinese Han population

Y. Xu, Li, B., Bao, Y. - Z., Zhang, X. - Y., Zhu, Z. - Y., Zhao, X. - F., Shi, Y. - N., Li, D., Chen, S. - H., Guo, Y., and Cui, C. - H., “MKL1-184C>T gene polymorphism is associated with coronary artery disease in the Chinese Han population”, vol. 13, pp. 590-597, 2014.

We investigated genetic susceptibility to coronary artery disease (CAD) by studying the association of MKL1 gene polymorphisms with CAD in the Chinese Han population. We performed a case-control study with 476 unrelated CAD patients and 325 non-CAD controls. All SNPs were genotyped with a TaqMan SNP genotyping assay. The distribution of MKL1-184C>T gene polymorphism in each group was in Hardy-Weinberg equilibrium. The frequency of the MKL1 T allele in the CAD group was significantly higher than in the control group (38.6 vs 30.8%).

Lack of association between a common polymorphism of the endothelial lipase gene and early-onset coronary artery disease in a Chinese Han population

G. J. Cai, He, G. P., Huang, Z. Y., and Qi, C. P., “Lack of association between a common polymorphism of the endothelial lipase gene and early-onset coronary artery disease in a Chinese Han population”, vol. 13, pp. 1059-1069, 2014.

A growing body of evidence suggests that the 584C/T polymorphism in the endothelial lipase (EL) gene contributes to the process of coronary artery disease (CAD). The present study aimed to reveal the potential relationship between the EL 584C/T gene polymorphism and early-onset CAD, CAD severity, and lipid levels in a Chinese Han population. Participants comprised 135 early-onset CAD patients and 166 controls. EL 584C/T genotypic and allelic frequencies were detected by PCR.

PTGS2 gene polymorphism -765G>C is associated with coronary artery disease: a meta-analysis

C. - L. Xuan, Yan, W., Xuan, L., and Xu, R. - H., “PTGS2 gene polymorphism -765G>C is associated with coronary artery disease: a meta-analysis”, vol. 13, pp. 1491-1496, 2014.

Previous studies focusing on the association of PTGS2 polymorphism -765G>C with coronary artery disease (CAD) have failed to reach the same conclusion. In the present study, we performed a meta-analysis to systematically summarize the possible association between PTGS2 polymorphism -765G>C and the risk of CAD. We conducted a search of case-control studies on the associations of PTGS2 with susceptibility to CAD in PubMed, EMBASE, and Chinese National Knowledge Infrastructure databases. Data from eligible studies were extracted for meta-analysis.

Relationship between the cholesterol ester transfer protein TaqIB polymorphism and the lipid-lowering effect of atorvastatin in patients with coronary atherosclerotic heart disease

J. Li, Zhang, L., Xie, N. Z., Deng, B., Lv, L. X., and Zheng, L. Q., “Relationship between the cholesterol ester transfer protein TaqIB polymorphism and the lipid-lowering effect of atorvastatin in patients with coronary atherosclerotic heart disease”, vol. 13, pp. 2140-2148, 2014.

This study aimed to investigate the relationship between the cholesterol ester transfer protein (CETP) gene TaqIB polymorphism and the lipid-lowering effect of atorvastatin in patients with coronary atherosclerotic heart disease. Two hundred eighty-eight patients were divided into a control group, an acute coronary syndrome (ACS) group, and a stable coronary heart disease (CHD) group.

Gene polymorphisms associated with susceptibility to coronary artery disease in Han Chinese people

Y. H. Liu, Zhou, Y. W., Yang, J. A., Tu, Z. G., Ji, S. Y., Huang, Z. Y., and Zhou, Z. J., “Gene polymorphisms associated with susceptibility to coronary artery disease in Han Chinese people”, vol. 13, pp. 2619-2627, 2014.

This study investigated 5 single nucleotide polymorphism (SNP) haplotypes in susceptibility genes for coronary artery disease (CAD) and the putative involvement of these SNPs in CAD in the Chi­nese Han population. From March 2008 to June 2009, we selected 119 CAD patients and 115 subjects not related to the CAD of Chinese Han or­igin as controls. The SNP genotypes were performed by multiplex SNaP­shot technology. The HNRPUL1 gene rs11881940T and GATA2 gene rs3803T loci were highly correlated with CAD (P

IL-6 gene promoter polymorphisms and risk of coronary artery disease in a Chinese population

G. Q. Sun, Wu, G. D., Meng, Y., Du, B., and Li, Y. B., “IL-6 gene promoter polymorphisms and risk of coronary artery disease in a Chinese population”, vol. 13, pp. 7718-7724, 2014.

We investigated the relationships between single nucleotide polymorphisms (SNPs) of the interleukin (IL)-6 gene 174 G>C (rs1800795), 572 G>C (rs1800796), and 597 G/A (rs1800797) and coronary artery disease (CAD) risk in a Chinese population. This case-control study recruited 296 CAD patients and 327 controls between January 2009 and May 2012. Genotyping of IL-6 174 G>C (rs1800795), 572 G>C (rs1800796), and 597 G/A (rs1800797) was performed on a 384-well plate format using the Sequenom MassARRAY platform.

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