Coronary heart disease

CYP2C19 polymorphisms in acute coronary syndrome patients undergoing clopidogrel therapy in Zhengzhou population

Y. M. Guo, Zhao, Z. C., Zhang, L., Li, H. Z., Li, Z., Sun, H. L., Guo, Y. M., Zhao, Z. C., Zhang, L., Li, H. Z., Li, Z., and Sun, H. L., “CYP2C19 polymorphisms in acute coronary syndrome patients undergoing clopidogrel therapy in Zhengzhou population”, vol. 15, p. -, 2016.

The goal of this study was to explore the polymorphisms of CYP2C19 (CYP2C19*2, CYP2C19*3) in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI) on clopidogrel therapy in Zhengzhou city for guidance on clinical medication and reduction in the incidence of thromboembolic events. Two hundred and thirty-four ACS patients undergoing PCI were included in the study, including 171 males (average age = 64.13 ± 12 years) and 63 females (average age = 67.86 ± 10.20 years).

Association of N-acetyltransferase-2 polymorphism with an increased risk of coronary heart disease in a Chinese population

J. D. Sun, Yuan, H., Hu, H. Q., Yu, H. M., Sun, J. D., Yuan, H., Hu, H. Q., and Yu, H. M., “Association of N-acetyltransferase-2 polymorphism with an increased risk of coronary heart disease in a Chinese population”, vol. 15, p. -, 2016.

We investigated the possible correlations between N-acetyltransferase-2 (NAT2) gene polymorphisms and the risk of coronary heart disease (CHD). CHD patients (113) and healthy controls (118) were enrolled from the First People’s Hospital of Yuhang between January 2013 and June 2014. The patients were divided into mild CHD (N = 72) and severe CHD (N = 41) subgroups. DNA samples were extracted and the distributions of NAT2 polymorphisms were examined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).

Correlation between the 677C>T polymorphism in the methylene tetrahydrofolate reductase gene and serum homocysteine levels in coronary heart disease

Y. Y. Chen, Wang, B. N., Yu, X. P., Chen, Y. Y., Wang, B. N., Yu, X. P., Chen, Y. Y., Wang, B. N., and Yu, X. P., “Correlation between the 677C>T polymorphism in the methylene tetrahydrofolate reductase gene and serum homocysteine levels in coronary heart disease”, vol. 15, p. -, 2016.

The aim of the current study was to explore the correlation between serum homocysteine (HCY) levels and the methylene tetrahydrofolate reductase (MTHFR) gene 677C/T polymorphism and coronary heart disease (CHD). We consecutively enrolled 208 patients with CHD confirmed by CTA or coronary angiography from our hospital. An additional 200 healthy volunteers were enrolled as the control group. Serum HCY levels, MTHFR C677T genotype, and other related indicators were evaluated for the two groups.

Male-specific association of the APC rs383830 T allele with the risk of coronary heart disease

J. Y. Zhong, Zheng, X. W., Ye, H. D., Cui, H. B., Du, W. P., Zhang, Z. X., Fei, X. H., Lin, S. Y., Wang, J., Su, J., Chen, X. M., and Duan, S. W., “Male-specific association of the APC rs383830 T allele with the risk of coronary heart disease”, vol. 14, pp. 11745-11751, 2015.

APC is a tumor suppressor gene that is involved in the processes of cell migration and adhesion, transcriptional activation, and apoptosis. The goal of this study was to evaluate the contribution of the APC rs383830 polymorphism to coronary heart disease (CHD) in Han Chinese. A total of 783 patients with CHD and 737 controls were tested in the current association study.

Significant interaction of APOE rs4420638 polymorphism with HDL-C and APOA-I levels in coronary heart disease in Han Chinese men

Y. Huang, Ye, H. D., Gao, X., Nie, S., Hong, Q. X., Ji, H. H., Sun, J., Zhou, S. J., Fei, B., Li, K. Q., Zhao, J. K., Wang, Z. P., Xu, M. Q., and Duan, S. W., “Significant interaction of APOE rs4420638 polymorphism with HDL-C and APOA-I levels in coronary heart disease in Han Chinese men”, vol. 14, pp. 13414-13424, 2015.

Apolipoprotein E (APOE) is recognized for its importance in lipoprotein metabolism and cardiovascular disease. We evaluated the association between APOE rs4420638 genotypes and circulating lipid concentrations along with the risk of coronary heart disease (CHD). We conducted a case-control study involving 1508 individuals to investigate the contribution of rs4420638 to the risk of CHD in Han Chinese. In addition, we performed a meta-analysis to evaluate the association between rs4420638 and CHD in Europeans and Asians.

Relationship between serum adiponectin and osteoprotegerin levels and coronary heart disease severity

H. L. Zhang and Jin, X., “Relationship between serum adiponectin and osteoprotegerin levels and coronary heart disease severity”, vol. 14, pp. 11023-11029, 2015.

This study aimed to explore serum adiponectin and osteoprotegerin levels in patients with coronary heart disease (CHD) and their correlation with inflammatory and ischemia factors. From September 2010 to Augest 2010, 347 CHD patients were enrolled for a retrospective analysis. Serum lipoprotein phospholipase A2 (Lp-PLA2), hypersensitive C-reactive protein (hs-CRP), ischemia modified albumin (IMA), and adiponectin and osteoprotegerin levels were detected and analyzed.

Subscribe to Coronary heart disease