CpG ODN 1826 enhances radiosensitivity of the human lung cancer cell line A549 in a rat model
“CpG ODN 1826 enhances radiosensitivity of the human lung cancer cell line A549 in a rat model”, vol. 14, pp. 9804-9812, 2015.
, This study investigated the effects of CpG ODN1826 plus radiotherapy (RT) on tumor growth and angiogenesis of subcutaneous tumor in a rat model. Four treatment groups were tested in which rats were injected with 100 μL CpG ODN1826 (1 μg/μL) or 100 μL vehicle, with and without exposure to 8 Gy after 2 h. At 7 days after inoculation of lung cancer cells, drugs were injected in the tumor and radiation was administered over 5 days, after which the rate of tumor inhibition was calculated.