CYP1A1

Association between the CYP1A1 polymorphisms and hepatocellular carcinoma: a meta-analysis

B. W. Yu, Zhang, L. Q., Teng, X. L., Zhang, Y., Zou, L. B., and Ying, H. Y., Association between the CYP1A1 polymorphisms and hepatocellular carcinoma: a meta-analysis, vol. 14, pp. 1076-1084, 2015.

Numerous studies have evaluated the association between CYP1A1 gene polymorphisms and hepatocellular carcinoma (HCC) risk. However, the specific association is still controversial. The aim of our study was to clarify the effects of CYP1A1 gene polymorphisms (3801 T>C and A2455G) on HCC risk by conducting a meta-analysis. We conducted searches of the literature published in PubMed and EMBASE databases up to April 2014. We estimated the pooled odds ratio with its 95% confidence interval to assess the association using a fixed or random-effects model.

Association of the CYP1A1 MspI and TNFα-308 polymorphisms with chronic obstructive pulmonary disease in Inner Mongolia

L. Yang, Li, F., Yan, M., and Su, X., Association of the CYP1A1 MspI and TNFα-308 polymorphisms with chronic obstructive pulmonary disease in Inner Mongolia, vol. 13, pp. 3209-3217, 2014.

Chronic obstructive pulmonary disease (COPD) is a progressive lung disease characterized by persistent airflow limitation. Smoking, occupational exposures, air pollution, and genetics are all risk factors. In the present study, we detected the cytochrome P4501A1 gene (CYP1A1) MspI polymorphism and the tumor necrosis factor alpha (TNFα)-308 single nucleotide polymorphism in COPD patients, and investigated their associations with smoking and COPD susceptibility in Inner Mongolia. A total of 101 COPD patients and 80 controls were enrolled in the study.

Association between CYP1A1m1 gene polymorphism and primary open-angle glaucoma

N. B. Costa, Silva, C. T. X., Frare, A. B., Silva, R. E., and Moura, K. K. V. O., Association between CYP1A1m1 gene polymorphism and primary open-angle glaucoma, vol. 13, pp. 10382-10389, 2014.

The CYP1A1 gene is related to the generation of secondary metabolites that are capable of inducing DNA damage. The CYP1A1m1 polymorphism has been examined in many studies, and is located in a region near loci that have been linked to glaucoma, including the locus GLC1I. As a result, this polymorphism has been related to several diseases that are influenced by exposure to xenobiotic as well as primary open-angle glaucoma.

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