Cytotoxicity

Dihydromyricetin induces cell apoptosis via a p53-related pathway in AGS human gastric cancer cells

F. J. Ji, Tian, X. F., Liu, X. W., Fu, L. B., Wu, Y. Y., Fang, X. D., and Jin, H. Y., Dihydromyricetin induces cell apoptosis via a p53-related pathway in AGS human gastric cancer cells, vol. 14, pp. 15564-15571, 2015.

The aim of the present study was to determine the anti­proliferative and pro-apoptotic effects of dihydromyricetin (DHM) on the AGS human gastric cancer cells and their underlying mechanisms. The effects of DHM on AGS cells were evaluated by using 3-(4, 5-di­methylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), lactate dehydrogenase, and Annexin V/propidium iodide (PI) double-staining assays. The underlying mechanisms were determined by using quanti­tative real-time polymerase chain reaction.

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