DARPP

BDNF and DARPP-32 genes are not risk factors for schizophrenia in the Malay population

H. C. Loh, Tang, P. Y., Tee, S. F., Chow, T. J., Cheah, Y. C., and Singh, S. S. J., BDNF and DARPP-32 genes are not risk factors for schizophrenia in the Malay population, vol. 11, pp. 725-730, 2012.

A number of studies have pointed to the association of BDNF (brain-derived neurotrophic factor) and DARPP-32 (dopamine- and cAMP-regulated phosphoprotein, 32 kDa) with schizophrenia. The purpose of this study was to determine whether these two genes are involved in the pathogenesis of schizophrenia in the Malay population. Two single nucleotide polymorphisms Val66Met of BDNF, -2036C>G and g.1238delG of DARPP-32 were genotyped in the Malay population in 200 patients with schizophrenia and 256 healthy controls.

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