Demethylase

Expression pattern of JMJD1C in oocytes and its impact on early embryonic development

C. H. Li, Gao, Y., Wang, S., Xu, F. F., Dai, L. S., Jiang, H., Yu, X. F., Chen, C. Z., Yuan, B., and Zhang, J. B., Expression pattern of JMJD1C in oocytes and its impact on early embryonic development, vol. 14, pp. 18249-18258, 2015.

Cell reprogramming mediated by histone methylation and demethylation is crucial for the activation of the embryonic genome in early embryonic development. In this study, we employed quantitative real-time polymerase chain reaction (qRT-PCR) to detect mRNA levels and expression patterns of all known histone demethylases in early germinal vesicle stage and in vitro-matured metaphase II (MII) oocytes (which are commonly used as donor cells for nuclear transfer).

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