Dexmedetomidine

In vitro effect of dexmedetomidine on the respiratory burst of neutrophils

S. L. Chen, Zhou, W., Hua, F. Z., Chen, Y., Zheng, X. L., Long, X. F., Lu, J., Chen, S. L., Zhou, W., Hua, F. Z., Chen, Y., Zheng, X. L., Long, X. F., and Lu, J., “In vitro effect of dexmedetomidine on the respiratory burst of neutrophils”, vol. 15, p. -, 2016.

The immunosuppressive effects of dexmedetomidine, a highly selective and widely used a2-adrenoceptor agonist for sedation, analgesia, and stress management, are investigated in vitro. In the present study, the respiratory burst of human neutrophils separated from venous blood was evaluated with dexmedetomidine treatment after Escherichia coli stimulation. The effects of five concentrations of dexmedetomidine (1, 5, 10, 50, 100 μg/mL) were evaluated by rhodamine in a flow cytometer.

Effects of prolonged anesthesia with dexmedetomidine, fentanyl, or remifentanil on the self-renewal of mouse embryonic stem cells

N. Zhang, Cai, Y. R., Yi, X. W., Xiao, Y. N., Chen, B., and Li, W. X., “Effects of prolonged anesthesia with dexmedetomidine, fentanyl, or remifentanil on the self-renewal of mouse embryonic stem cells”, vol. 14, pp. 17809-17819, 2015.

Previous study has indicated that exposure to anesthesia in early development leads to neuro-apoptosis and is followed by long-term cognitive dysfunction. Given that larger numbers of pregnant women currently receive anesthesia during the first trimester, we wanted to mimic this process in vitro using mouse embryonic stem cells (mESCs) and to explore how different anesthetics affect the self-renewal of mESCs. In the present study, mESCs were exposed to dexmedetomidine, fentanyl, or remifentanil at clinical concentrations for 48 h.

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