Diagnosis

Combination of IL-6, IL-10, and MCP-1 with traditional serum tumor markers in lung cancer diagnosis and prognosis

Y. W. Pan, Zhou, Z. G., Wang, M., Dong, J. Q., Du, K. P., Li, S., Liu, Y. L., Lv, P. J., Gao, J. B., Pan, Y. W., Zhou, Z. G., Wang, M., Dong, J. Q., Du, K. P., Li, S., Liu, Y. L., Lv, P. J., and Gao, J. B., “Combination of IL-6, IL-10, and MCP-1 with traditional serum tumor markers in lung cancer diagnosis and prognosis”, vol. 15, no. 4, p. -, 2016.

INTRODUCTION

Transcriptional analysis of atrial and ventricular muscles from rats

Y. Zhi, Cao, Z., Li, Q. H., Li, X. L., Sun, Y., Zhang, T., Zhang, Q., Zhi, Y., Cao, Z., Li, Q. H., Li, X. L., Sun, Y., Zhang, T., Zhang, Q., Zhi, Y., Cao, Z., Li, Q. H., Li, X. L., Sun, Y., Zhang, T., and Zhang, Q., “Transcriptional analysis of atrial and ventricular muscles from rats”, vol. 15, p. -, 2016.

Previous studies have used microarray technology to explore gene expression differences between the atrium and the ventricle. However, selection criteria for the differentially expressed genes (DEGs) based only on either the fold change or the P value in these studies. Here, we aim to further identify the DEGs by setting a P value threshold of 2, which may yield more specific gene expression differences between the atrium and the ventricle.

Circulating miR-125b as a biomarker of Ewing's sarcoma in Chinese children

C. L. Nie, Ren, W. H., Ma, Y., Xi, J. S., and Han, B., “Circulating miR-125b as a biomarker of Ewing's sarcoma in Chinese children”, vol. 14, pp. 19049-19056, 2015.

Previous studies indicated that microRNA-125b (miR-125b) has an important role in the progression of Ewing’s sarcoma (ES). The purpose of the current study was to examine expression changes of miR-125b in the serum of ES patients and evaluate if the expression level of miR-125b could serve as a new biomarker for ES. This study was performed on patients who underwent surgical resection at our hospital between 2005 and 2013 after an initial diagnosis of ES.

MicroRNAs as novel biomarkers for the differentiation of malignant versus benign thyroid lesions: a meta-analysis

G. J. Zhou, Xiao, M., Zhao, L. N., Tang, J. G., and Zhang, L., “MicroRNAs as novel biomarkers for the differentiation of malignant versus benign thyroid lesions: a meta-analysis”, vol. 14, pp. 7279-7289, 2015.

The aim of this meta-analysis was to systematically evaluate the diagnostic accuracy of microRNAs (miRNAs) in distinguishing malignant thyroid lesions from benign ones and to determine the potential of miRNAs as diagnostic biomarkers for thyroid cancer. The random-effect model was used to summarize the pooled estimates of diagnostic accuracy, including sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), and diagnostic odds ratio (DOR).

Accuracy of enzyme-linked immunospot assay for diagnosis of pleural tuberculosis: a meta-analysis

Z. Z. Li, Qin, W. Z., Li, L., Wu, Q., and Wang, Y. J., “Accuracy of enzyme-linked immunospot assay for diagnosis of pleural tuberculosis: a meta-analysis”, vol. 14, pp. 11672-11680, 2015.

Current methods for diagnosing tuberculous pleurisy are poor. Some studies have explored the diagnostic value of a pleural effusion enzyme-linked immunospot (ELISPOT) assay, but its accuracy remains controversial. Therefore, we performed a meta-analysis of the existing evidence on the ability of the ELISPOT assay to diagnose tuberculous pleurisy. We systematically searched PubMed, Google Scholar, and EMBASE databases for studies measuring the sensitivity, specificity, and other measures of accuracy of the pleural effusion ELISPOT assay for diagnosis of tuberculous pleurisy.

Investigation of the value of miR-21 in the diagnosis of early stage HCC and its prognosis: a meta-analysis

S. R. Yan, Liu, Z. J., Yu, S., and Bao, Y. X., “Investigation of the value of miR-21 in the diagnosis of early stage HCC and its prognosis: a meta-analysis”, vol. 14, pp. 11573-11586, 2015.

The diagnostic and prognostic value of miR-21 has been examined for hepatocellular carcinoma (HCC), with inconsistent results. Present meta-analysis summarized the diagnostic accuracy and the predictive role for survival of miR-21 in patients with HCC. All eligible studies were searched using PubMed, EMBASE, and Chinese National Knowledge Infrastructure (CNKI) databases up to October 2014. For the diagnostic meta-analysis, the indices of miR-21 in the diagnosis of HCC were pooled using bivariate random-effect approach models.

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