Dicentric Y

Molecular analysis of an idic(Y)(qter→p11.32::p11.32→qter) chromosome from a female patient with a complex karyotype

R. Fernandez and Pasaro, E., Molecular analysis of an idic(Y)(qter→p11.32::p11.32→qter) chromosome from a female patient with a complex karyotype, vol. 5, pp. 399-406, 2006.

A female patient with a structurally abnormal idic(Y) (p11.32) chromosome was studied using fluorescence in situ hybridization and PCR to define the precise position of the breakpoint. The patient had a complex mosaic karyotype with eight cell lines and at least two morphologically distinct derivatives from the Y chromosome. The rearrangement was a result of a meiosis I exchange between sister chromatids at the pseudoautosomal region, followed by centromere misdivision at meiosis II.

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