Different stages

Hypoxia-inducible factor-1α expression in the different stages of rat thromboangiitis obliterans

T. He, Qu, B. H., Wang, D. L., and Hu, M., Hypoxia-inducible factor-1α expression in the different stages of rat thromboangiitis obliterans, vol. 14, pp. 6715-6722, 2015.

We investigated the expression and effects of hypoxia-inducible factor-1α (HIF-1α) in rat thromboangiitis obliterans (TO). Rats were divided into sham and model groups. The model group was further divided into groups based on observation duration. Lauric acid was injected below an artery clamp to simulate TO in the model group; saline was used in the sham group. Clamps were removed 15 min after injection in both groups, and physiological changes were observed at different times (gross observation and hematoxylin and eosin staining).

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