Differentially expressed genes

Biological analysis of chronic lymphocytic leukemia: integration of mRNA and microRNA expression profiles

L. Dong, Bi, K. H., Huang, N., Chen, C. Y., Dong, L., Bi, K. H., Huang, N., Chen, C. Y., Dong, L., Bi, K. H., Huang, N., and Chen, C. Y., Biological analysis of chronic lymphocytic leukemia: integration of mRNA and microRNA expression profiles, vol. 15, p. -, 2016.

Chronic lymphocytic leukemia (CLL) is a disease that involves progressive accumulation of nonfunctioning lymphocytes and has a low cure rate. There is an urgent requirement to determine the molecular mechanism underlying this disease in order to improve the early diagnosis and treatment of CLL. In this study, genes differentially expressed between CLL samples and age-matched controls were identified using microRNA (miRNA) and mRNA expression profiles. Differentially expressed (DE) miRNA targets were predicted by combining five algorithms.

Critical genes in head and neck squamous cell carcinoma revealed by bioinformatic analysis of gene expression data

B. Wang, Wang, T., Cao, X. L., and Li, Y., Critical genes in head and neck squamous cell carcinoma revealed by bioinformatic analysis of gene expression data, vol. 14, pp. 17406-17415, 2015.

In this study, bioinformatic analysis of gene expression data of head and neck squamous cell carcinoma (HNSCC) was performed to identify critical genes. Gene expression data of HNSCC were downloaded from the Cancer Genome Atlas (TCGA) and differentially expressed genes were determined through significance analysis of microarrays. Protein-protein interaction networks were constructed and used to identify hub genes. Functional enrichment analysis was performed with DAVID. Relevant microRNAs, transcription factors, and small molecule drugs were predicted by the Fisher exact test.

Identification of genes and pathways related to lipopolysaccharide signaling in duckling spleens

B. Deng, Yu, T., Liu, W., Ye, S. Q., Wang, L. X., Yang, Y., Gong, P., Ran, Z. P., Huang, H. J., and Wen, J. H., Identification of genes and pathways related to lipopolysaccharide signaling in duckling spleens, vol. 14, pp. 17312-17321, 2015.

Lipopolysaccharide (LPS), the major component of the outer cell wall of Gram-negative bacteria, activates the immune system and threatens the health of livestock and poultry. However, little is known about the genes and pathways involved in the immune response of ducklings to LPS. To elucidate the genes involved in the response of 7-day-old duckling spleens treated with LPS, RNA from LPS-treated and control duckling spleens was analyzed by RNA-Seq. The results showed 11,095 and 10,840 genes with >10 clean reads in the LPS-treated and control groups, respectively.

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