Differentiation

Growth factor progranulin blocks tumor necrosis factor-α-mediated inhibition of osteoblast differentiation

N. Wang, Zhang, J., Yang, J. X., Wang, N., Zhang, J., and Yang, J. X., Growth factor progranulin blocks tumor necrosis factor-α-mediated inhibition of osteoblast differentiation, vol. 15, p. -, 2016.

Tumor necrosis factor-α (TNF-α) stimulates osteoclast differentiation and suppresses osteoblast differentiation, leading to bone loss and decreased bone mass in local inflammation areas in patients with rheumatoid arthritis. The growth factor progranulin (PGRN) is expressed in various types of cells and play crucial roles in the pathogenesis of atherosclerosis and arthritis by blocking TNF-α. Here, we investigated the role of PGRN in blocking TNF-α-mediated inhibition of osteoblast differentiation and the regulatory mechanism.

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