Disease susceptibility

CD40 rs4810485 T>G polymorphism and susceptibility to ankylosing spondylitis in the Latvian population

J. Zepa, Silamiķele, L., Bulina, I., Lavrentjevs, V., Trapina, I., Klovins, J., Andersone, D., Lejnieks, A., and Nikitina-Zake, L., “CD40 rs4810485 T>G polymorphism and susceptibility to ankylosing spondylitis in the Latvian population”, Genetics and Molecular Research, vol. 17, 2018.

Lack of association between MD-2 promoter gene variants and tuberculosis

Y. Xue, Zhao, Z. Q., Hong, D., Zhao, M. Y., Zhang, Y. X., Wang, H. J., Wang, Y., and Li, J. C., “Lack of association between MD-2 promoter gene variants and tuberculosis”, vol. 9, pp. 1584-1590, 2010.

Myeloid differentiation-2 (MD-2) is an essential component of the CD14-TLR4/MD-2 receptor complex involved in microbial cell wall component recognition during infection. Genetic variations in the MD-2 gene may influence human susceptibility to infectious diseases. To date, a predisposition of MD-2 gene variants to contract tuberculosis has not been reported. We investigated whether MD-2 gene polymorphisms were associated with the development of tuberculosis in a Chinese population.

Association of TIRAP (MAL) gene polymorhisms with susceptibility to tuberculosis in a Chinese population

Y. X. Zhang, Xue, Y., Zhao, M. Y., Wang, H. J., Li, J. C., Liu, J. Y., Li, F. J., and Zhou, J. M., “Association of TIRAP (MAL) gene polymorhisms with susceptibility to tuberculosis in a Chinese population”, vol. 10, pp. 7-15, 2011.

Toll-interleukin 1 receptor (TIR) domain containing adaptor protein (TIRAP; also known as MAL) is an essential adaptor molecule in Toll-like receptor signaling, involved in activating the innate immune response during infection. Genetic variations in the TIRAP gene may influence human susceptibility to infectious disease. To date, in the Chinese population, a possible predisposition of TIRAP gene variants to tuberculosis has not been reported.

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