Disrupted pathways

Systematic tracking of altered modules identifies disrupted pathways in teratozoospermia

Z. Q. Huang, Wang, G. X., Jiang, X. L., Tian, E. P., Yao, W. L., Zeng, T., Huang, Z. Q., Wang, G. X., Jiang, X. L., Tian, E. P., Yao, W. L., Zeng, T., Huang, Z. Q., Wang, G. X., Jiang, X. L., Tian, E. P., Yao, W. L., and Zeng, T., Systematic tracking of altered modules identifies disrupted pathways in teratozoospermia, vol. 15, p. -, 2016.

The objective of this study was to identify disrupted pathways in teratozoospermia by systematically tracking dysregulated modules in reweighted protein-protein interaction (PPI) networks. We inferred and reweighted the PPI networks of normal and teratozoospermia groups based on Spearman correlation coefficients. Modules in the PPI networks were explored via a clique-merging algorithm and altered modules were identified based on maximum weight bipartite matching.

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