Diterpene

The epimer of kaurenoic acid from Croton antisyphiliticus is cytotoxic toward B-16 and HeLa tumor cells through apoptosis induction

V. C. Fernandes, Pereira, S. I. V., Coppede, J., Martins, J. S., Rizo, W. F., Beleboni, R. O., Marins, M., Pereira, P. S., Pereira, A. M. S., and Fachin, A. L., The epimer of kaurenoic acid from Croton antisyphiliticus is cytotoxic toward B-16 and HeLa tumor cells through apoptosis induction, vol. 12, pp. 1005-1011, 2013.

Cancer has become the leading cause of death in developing countries due to increased life expectancy of the population and changes in lifestyle. Studies on active principles of plant have motivated researchers to develop new antitumor agents that are specific and effective for treatment of neoplasms. Kaurane diterpenes are considered important compounds in the development of new and highly effective anticancer chemotherapeutic agents due to their cytotoxic properties in the induction of apoptosis.

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