DNA methylation

CpG island evolution in the mammalian DHRS4 gene cluster and its role in the regulation of gene transcription

Z. Su, Liu, G., Song, X., Liang, B., Chang, X., Huang, D., Su, Z., Liu, G., Song, X., Liang, B., Chang, X., and Huang, D., CpG island evolution in the mammalian DHRS4 gene cluster and its role in the regulation of gene transcription, vol. 15, p. -, 2016.

The dehydrogenase/reductase (SDR family) member 4 (DHRS4) gene is copied during mammalian evolution; therefore, while only one DHRS4 gene is expressed in the mouse genome, the gene cluster consists of two (DHRS4 and DHRS4L1) and three (DHRS4, DHRS4L2, and DHRS4L1) copies in chimpanzees and humans, respectively.

Prediction efficiency of PITX2 DNA methylation for prostate cancer survival

Z. M. Luan, Zhang, H., Qu, X. L., Luan, Z. M., Zhang, H., Qu, X. L., Luan, Z. M., Zhang, H., and Qu, X. L., Prediction efficiency of PITX2 DNA methylation for prostate cancer survival, vol. 15, p. -, 2016.

This study determined the level of PITX2 methylation in prostate cancer and benign tissues and its relationship with the postoperative survival rate. Forty-four patients with prostate cancer who underwent radical prostatectomy and 43 patients with benign prostatic hyperplasia were selected. DNA was extracted from the tissues and PITX2 methylation status was quantitatively analyzed by using the EpiTect MethyLight method.

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