DNA methylation

Functional analysis of OCIAD2 in hepatoblastoma

M. Minato, Honda, S., Miyagi, H., and Taketomi, A., “Functional analysis of OCIAD2 in hepatoblastoma”, Genetics and Molecular Research, vol. 21, no. 1, 2022.

DNA methylation profile of the DKK2 gene as a biomarker in patients with colorectal cancer

T. D. Silva, Felipe, A. V., Vidigal, V. M., Saad, S. S., and Forones, N. M., “DNA methylation profile of the DKK2 gene as a biomarker in patients with colorectal cancer”, Genetics and Molecular Research, vol. 16, no. 4, 2017.

Genome-wide analysis of salinity-stress induced DNA methylation alterations in cotton (Gossypium hirsutum L.) using the Me-DIP sequencing technology.

X. K. Lu, Shu, N., Wang, J. J., Chen, X. G., Wang, D. L., Wang, S., Fan, W. L., Guo, X. N., Guo, L. X., and Ye, W. W., “Genome-wide analysis of salinity-stress induced DNA methylation alterations in cotton (Gossypium hirsutum L.) using the Me-DIP sequencing technology.”, Genet Mol Res, vol. 16, no. 2, 2017.

Promoter identification and analysis of key glycosphingolipid biosynthesis-globo series pathway genes in piglets.

W. Y. Qin, Gan, L. N., Xia, R. W., Dong, W. H., Sun, S. Y., Zhu, G. Q., Wu, S. L., and Bao, W. B., “Promoter identification and analysis of key glycosphingolipid biosynthesis-globo series pathway genes in piglets.”, Genet Mol Res, vol. 16, no. 2, 2017.

DNA methylation in sugarcane somaclonal variants assessed through methylation-sensitive amplified polymorphism.

J. H. M. B. Francischini, Kemper, E. L., Costa, J. B., Manechini, J. R. V., and Pinto, L. R., “DNA methylation in sugarcane somaclonal variants assessed through methylation-sensitive amplified polymorphism.”, Genet Mol Res, vol. 16, no. 2, 2017.

Analysis of allopolyploidy-induced rapid genetic and epigenetic changes and their relationship in wheat.

T. Qiu, Dong, Y. Z., Yu, X. M., Zhao, N., and Yang, Y. F., “Analysis of allopolyploidy-induced rapid genetic and epigenetic changes and their relationship in wheat.”, Genet Mol Res, vol. 16, no. 2, 2017.

Mechanism of SEMA3B gene silencing and clinical significance in glioma

C. H. Pang, Du, W., Long, J., Song, L. J., Pang, C. H., Du, W., Long, J., Song, L. J., Pang, C. H., Du, W., Long, J., and Song, L. J., “Mechanism of SEMA3B gene silencing and clinical significance in glioma”, vol. 15, p. -, 2016.

The aim of the current study was to explore mechanisms of SEMA3B gene expression and its clinical significance in glioma, and provide a theoretical foundation for investigating individualized treatment in glioma. Paraffin-embedded tissues from 43 patients with a confirmed clinical diagnosis of glioma following neurosurgery at the First Affiliated Hospital of Zhengzhou University from December 2013 to April 2014 were selected randomly.

Relationship of EGFR DNA methylation with the severity of non-small cell lung cancer

J. Li, Jia, X. F., Liu, J., Liu, J. J., and Zhao, H. B., “Relationship of EGFR DNA methylation with the severity of non-small cell lung cancer”, vol. 14, pp. 11915-11923, 2015.

The aim of this study was to study the relationship of EGFR DNA methylation with the severity of non-small-cell lung cancer (NSCLC). We enrolled 54 patients with NSCLC between March 2013 and June 2014 from Department of Cardiothoracic Surgery in our hospital. The methylation levels in the promoter region of the EGFR gene in cancerous and pericarcinomatous tissue were tested by pyrosequencing. EGFR mRNA expression levels were detected by real-time reverse-transcription polymerase chain reaction. The SPSS software was used for data analysis.

Glucocorticoid receptor gene (NR3C1) promoter is hypermethylated in Thai females with major depressive disorder

M. Nantharat, Wanitchanon, T., Amesbutr, M., Tammachote, R., and Praphanphoj, V., “Glucocorticoid receptor gene (NR3C1) promoter is hypermethylated in Thai females with major depressive disorder”, vol. 14, pp. 19071-19079, 2015.

Major depressive disorder (MDD) has been associated with the stress response in the brain, which is controlled by the hypothalamic-pituitary-adrenal (HPA) axis. This HPA negative feedback mechanism acts via the activation of glucocorticoid receptor, which is encoded by the NR3C1 gene. The methylation status at the promoter of NR3C1 has been correlated with traumatic experiences in early life, which develop into mental disorder.

Promoter and first exon methylation regulate porcine FASN gene expression

K. R. Long, Ma, J. D., Chen, L., Wang, P. J., He, D. F., Li, M. Z., and Li, X. W., “Promoter and first exon methylation regulate porcine FASN gene expression”, vol. 14, pp. 8443-8450, 2015.

DNA methylation is a stable epigenetic mark mediating gene expression. Methylation is crucial for diverse biological processes, including aging and embryo development. FASN (fatty acid synthase) plays an important role in de novo lipogenesis, through catalyzing the reductive synthesis of long-chain fatty acids. In this study, we investigated the FASN gene expression pattern and corresponding DNA methylation status in the inner layer of backfat from Jinhua pigs at different developmental stages.

Pages