DNA methylation

CpG island evolution in the mammalian DHRS4 gene cluster and its role in the regulation of gene transcription

Z. Su, Liu, G., Song, X., Liang, B., Chang, X., Huang, D., Su, Z., Liu, G., Song, X., Liang, B., Chang, X., and Huang, D., CpG island evolution in the mammalian DHRS4 gene cluster and its role in the regulation of gene transcription, vol. 15, p. -, 2016.

The dehydrogenase/reductase (SDR family) member 4 (DHRS4) gene is copied during mammalian evolution; therefore, while only one DHRS4 gene is expressed in the mouse genome, the gene cluster consists of two (DHRS4 and DHRS4L1) and three (DHRS4, DHRS4L2, and DHRS4L1) copies in chimpanzees and humans, respectively.

Correlation between methylation of the E-Cadherin gene and malignancy of prostate cancer

S. Q. Zhang, Zhang, G. Q., Zhang, L., Zhang, S. Q., Zhang, G. Q., and Zhang, L., Correlation between methylation of the E-Cadherin gene and malignancy of prostate cancer, vol. 15, p. -, 2016.

Prostate cancer is a common malignant tumor in males with an unclear pathogenic mechanism. As one epigenetic regulation mechanism, DNA methylation of the whole genome and specific gene(s) plays critical roles in pathogenesis, progression, diagnosis, and treatment of prostate cancer. The E-Cadherin gene is involved in cell metabolism and has been suggested to be related with malignancy of multiple tumors. This study investigated the correlation between E-Cadherin methylation and malignancy of prostate cancer.

Prediction efficiency of PITX2 DNA methylation for prostate cancer survival

Z. M. Luan, Zhang, H., Qu, X. L., Luan, Z. M., Zhang, H., Qu, X. L., Luan, Z. M., Zhang, H., and Qu, X. L., Prediction efficiency of PITX2 DNA methylation for prostate cancer survival, vol. 15, p. -, 2016.

This study determined the level of PITX2 methylation in prostate cancer and benign tissues and its relationship with the postoperative survival rate. Forty-four patients with prostate cancer who underwent radical prostatectomy and 43 patients with benign prostatic hyperplasia were selected. DNA was extracted from the tissues and PITX2 methylation status was quantitatively analyzed by using the EpiTect MethyLight method.

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