Drug resistance

Reversal of cisplatin resistance in non-small cell lung cancer stem cells by Taxus chinensis var.

Y. Q. Jiang, Xu, X. P., Guo, Q. M., Xu, X. C., Liu, Q. Y., An, S. H., Xu, J. L., Su, F., Tai, J. B., Jiang, Y. Q., Xu, X. P., Guo, Q. M., Xu, X. C., Liu, Q. Y., An, S. H., Xu, J. L., Su, F., and Tai, J. B., Reversal of cisplatin resistance in non-small cell lung cancer stem cells by Taxus chinensis var., vol. 15, p. -, 2016.

Drug resistance in cells is a major impedance to successful treatment of lung cancer. Taxus chinensis var. inhibits the growth of tumor cells and promotes the synthesis of interleukins 1 and 2 and tumor necrosis factor, enhancing immune function. In this study, T. chinensis var.-induced cell death was analyzed in lung cancer cells (H460) enriched for stem cell growth in a defined serum-free medium. Taxus-treated stem cells were also analyzed for Rhodamine 123 (Rh-123) expression by flow cytometry, and used as a standard functional indicator of MDR.

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