Drug resistance protein

Preliminary study of the effects of β-elemene on MCF-7/ADM breast cancer stem cells

Y. Dong, Li, L., Wang, L., Zhou, T., Liu, J. W., and Gao, Y. J., Preliminary study of the effects of β-elemene on MCF-7/ADM breast cancer stem cells, vol. 14, pp. 2347-2355, 2015.

We examined expression differences in breast cancer stem cells (BCSCs) of the doxorubicin-resistant breast cancer cell line MCF-7/ADM and doxorubicin-sensitive cell line MCF-7/S. The effects of Chinese medicine β-elemene on BCSCs and resistance protein expression were determined. The serum-free cell culture method was used for cell culture, and morphology was observed to determine the rate of cell sphere formation. Reverse transcription-polymerase chain reaction was used to detect breast cancer resistance protein (BCRP) and P-glycoprotein (P-gp) gene expression.

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