Dyslipidemia

Association of APOA1 gene polymorphisms (rs670, rs5069, and rs2070665) with dyslipidemia in the Kazakhs of Xinjiang

D. W. Feng, Ma, R. L., Guo, H., He, J., Yan, Y. Z., Muratbek,, Niu, Q., Li, S. G., Rui, D. S., Sun, F., Zhang, M., Zhang, J. Y., Ding, Y. S., Liu, J. M., Wang, K., Guo, S. X., Feng, D. W., Ma, R. L., Guo, H., He, J., Yan, Y. Z., Muratbek,, Niu, Q., Li, S. G., Rui, D. S., Sun, F., Zhang, M., Zhang, J. Y., Ding, Y. S., Liu, J. M., Wang, K., Guo, S. X., Feng, D. W., Ma, R. L., Guo, H., He, J., Yan, Y. Z., Muratbek,, Niu, Q., Li, S. G., Rui, D. S., Sun, F., Zhang, M., Zhang, J. Y., Ding, Y. S., Liu, J. M., Wang, K., and Guo, S. X., Association of APOA1 gene polymorphisms (rs670, rs5069, and rs2070665) with dyslipidemia in the Kazakhs of Xinjiang, vol. 15, p. -, 2016.

The aim of this study was to investigate the potential association between apolipoprotein A1 (APOA1) gene rs670, rs5069, and rs2070665 polymorphisms and dyslipidemia in the Kazakh population of Xinjiang, China. Matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF-MS) was used to identify APOA1 (rs670, rs5069, and rs2070665) genotypes in 736 subjects (341 dyslipidemia patients and 395 control subjects).

Relationship of the APOA5/A4/C3/A1 gene cluster and APOB gene polymorphisms with dyslipidemia

H. J. Ou, Huang, G., Liu, W., Ma, X. L., Wei, Y., Zhou, T., and Pan, Z. M., Relationship of the APOA5/A4/C3/A1 gene cluster and APOB gene polymorphisms with dyslipidemia, vol. 14, pp. 9277-9290, 2015.

We determined the alleles of ten single nucleotide poly­morphisms (SNPs) in the APOA5/A4/C3/A1 gene cluster and in APOB in Han Chinese from Xinjiang Shihezi, China using MALDI-TOF mass spectrometry, and explored the correlation between these SNPs and dyslipidemia through a case-control study design with 250 pa­tients and 250 normal controls. All SNPs except for APOA5 rs2072560 conformed to Hardy-Weinberg equilibrium (all P > 0.05).

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