EGFR mutation

Comparison of EGFR mutation rates in lung adenocarcinoma tissue and pleural effusion samples

Y. Guan, Wang, Z. J., Wang, L. Q., Hua, D. F., Liu, J., Guan, Y., Wang, Z. J., Wang, L. Q., Hua, D. F., Liu, J., Guan, Y., Wang, Z. J., Wang, L. Q., Hua, D. F., and Liu, J., Comparison of EGFR mutation rates in lung adenocarcinoma tissue and pleural effusion samples, vol. 15, p. -, 2016.

The goal of the current study was to investigate the differences in epidermal growth factor receptor (EGFR) mutation rates in tumor tissue and pleural effusion specimens from patients with lung adenocarcinoma. PCR amplification and gene sequencing were used to detect EGFR mutations in exons 18, 19, 20, and 21 in tumor tissue and pleural effusion samples from 50 patients with advanced lung adenocarcinoma. The EGFR mutation rate was 34.0% in tissue samples from patients with advanced lung adenocarcinoma. There were 11 cases with exon 19 mutations and 6 cases with exon 21 mutations.

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