Endocrine disruptor

Effects of 17α-methyltestosterone on the reproduction of the freshwater snail Biomphalaria glabrata

C. L. G. Rivero-Wendt, Borges, A. C., Oliveira-Filho, E. C., Miranda-Vilela, A. L., Ferreira, M. F. N., and Grisolia, C. K., Effects of 17α-methyltestosterone on the reproduction of the freshwater snail Biomphalaria glabrata, vol. 13, pp. 605-615, 2014.

17-α-methyltestosterone (MT) is a synthetic hormone used in fish hatcheries to induce male monosex. Snails hold promise as possible test models to assess chemicals acting on the endocrine system. Biomphalaria glabrata is an aquatic gastropod mollusk (Pulmonata, Planorbidae) that can be easily maintained in aquaria, predisposing the species for use in ecotoxicological testing. This study evaluated the reproductive effects of MT on B. glabrata by examining histological changes and its reproductive performance.

Cytogenetic toxicity and gonadal effects of 17 α-methyltestosterone in Astyanax bimaculatus (Characidae) and Oreochromis niloticus (Cichlidae)

C. L. G. Rivero-Wendt, Miranda-Vilela, A. L., Ferreira, M. F. N., Borges, A. M., and Grisolia, C. K., Cytogenetic toxicity and gonadal effects of 17 α-methyltestosterone in Astyanax bimaculatus (Characidae) and Oreochromis niloticus (Cichlidae), vol. 12, pp. 3862-3870, 2013.

The synthetic hormone, 17-α-methyltestosterone (MT), is used in fish hatcheries to induce male monosex. Androgenic effects on various fish species have been reported; however, few studies have assessed possible genotoxic effects, although there are concerns about such effects in target and non-target species. We evaluated genotoxic and gonadal effects of MT in adult tilapia (Oreochromis niloticus) and Astyanax bimaculatus (a common native non-target fish in Brazil). Fish were fed for 28 days with ration containing MT (60 mg/L), a normal dose used in fish farming.

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