Endometrial cancer

Contribution of catechol-O-methyltransferase Val158Met polymorphism to endometrial cancer risk in postmenopausal women: a meta-analysis

G. Lin, Zhao, J., Wu, J., R. O, A., Zhang, W. - H., Zhang, Y., and Yu, L., Contribution of catechol-O-methyltransferase Val158Met polymorphism to endometrial cancer risk in postmenopausal women: a meta-analysis, vol. 12, pp. 6442-6453, 2013.

Catechol-O-methyltransferase (COMT) is a critical enzyme to detoxify the carcinogenic catechol estrogen and the Val158Met polymorphism of COMT could influence its enzymatic activity. Recent epidemiological studies have investigated the correlation of COMT Val158Met polymorphism with endometrial cancer risk; however, the results are inconsistent. To better evaluate the role of COMT Val158Met in endometrial carcinogenesis, we performed this meta-analysis, considering menopausal status, study quality, ethnicity, and source of controls.

Meta-analysis of an association of codon 72 polymorphisms of the p53 gene with increased endometrial cancer risk

Y. Gu, Zhou, X., and Zhang, S. L., Meta-analysis of an association of codon 72 polymorphisms of the p53 gene with increased endometrial cancer risk, vol. 10, pp. 3609-3619, 2011.

Polymorphisms of the p53 gene have been associated with susceptibility to endometrial cancer. However, whether there is a specific association is still controversial. We investigated a possible association between p53 codon 72 polymorphism and endometrial cancer risk by conducting a meta-analysis. Publications addressing this association were selected from the Pubmed, Embase and CBM databases (up to January 2011). Data were extracted from the studies by two independent reviewers. The meta-analysis was performed using RevMan 5.0.25 and STATA 9.2 softwares.

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