Endoplasmic reticulum stress

Effects of probucol on cultured human umbilical vein endothelial cells injured by hypoxia/reoxygenation

Y. L. Chai, Xu, J. Z., Zhang, Y. L., Sheng, G. T., Chai, Y. L., Xu, J. Z., Zhang, Y. L., and Sheng, G. T., Effects of probucol on cultured human umbilical vein endothelial cells injured by hypoxia/reoxygenation, vol. 15, p. -, 2016.

There is increasing evidence suggesting that endoplasmic reticulum stress (ERS) plays an important role in the initiation and development of atherosclerosis. This study was designed to examine the effect of probucol on cultured human umbilical vein endothelial cells (HUVECs) injured by hypoxia/reoxygenation (H/R) and the potential mechanisms involving ERS. Injured HUVECs induced by Na2S2O4 served as an H/R model in vitro. The concentration of probucol in this study ranged from 3 to 27 μM.

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