Endothelial nitric oxide synthase

Establishment of a rabbit model of coronary artery bypass graft and endothelial nitric oxide synthase gene transfection

Y. Zhu, Wang, H. - S., Li, X. - M., and Wang, Z. - W., Establishment of a rabbit model of coronary artery bypass graft and endothelial nitric oxide synthase gene transfection, vol. 14, pp. 1479-1486, 2015.

This study established an animal model of coronary artery bypass graft (CABG) surgery. The human endothelial nitric oxide synthase (eNOS) gene was transfected into grafted arterial walls to verify transfection efficiency. Forty rabbits were randomized into the following 4 equal groups: 1) eNOS gene transfection group (eNOS group); 2) empty eNOS gene transfection group (empty gene group); 3) control group; 4) normal femoral artery group. Grafted arteries, and normal carotid and femoral artery specimens were obtained 3 weeks later.

Effect of Xin Mai Jia on atherosclerosis in rats

P. Li, Pan, G. P., Jia, M., Wang, Q. Q., Guo, Z. G., Zhao, F. R., Lei, G. L., Wan, G. R., and Wan, G. M., Effect of Xin Mai Jia on atherosclerosis in rats, vol. 14, pp. 6018-6027, 2015.

We investigated the therapeutic effect of Xin Mai Jia (XMJ) on atherosclerosis (AS) in rats. Rat models of AS were estab­lished by peritoneally injecting vitamin D, feeding a high-fat diet, and inducing balloon injuries in rats. The stomachs of the rats were irrigated continuously for 10 weeks with XMJ. Blood lipid- and hemorheology-related indices of blood samples were detected. Pathological changes in the right common carotid arterial tissues were also determined.

Association between VEGF and eNOS gene polymorphisms and lumbar disc degeneration in a young Korean population

I. B. Han, Ropper, A. E., Teng, Y. D., Shin, D. A., Jeon, Y. J., Park, H. M., Shin, D. E., Park, Y. S., Kim, K. N., and Kim, N. - K., Association between VEGF and eNOS gene polymorphisms and lumbar disc degeneration in a young Korean population, vol. 12, pp. 2294-2305, 2013.

Disturbances in blood flow to intervertebral discs (IVD) play an important role in IVD degeneration. Vascular endothelial growth factor (VEGF) and endothelial nitric oxide synthase (eNOS) are extremely important angiogenic factors for vasodilation and neovascularization. We investigated the relationship between single nucleotide polymorphisms (SNPs) of the VEGF and eNOS genes and genetic susceptibility to lumbar IVD degeneration in a young adult Korean population.

Polymorphisms in the endothelial nitric oxide synthase gene associated with recurrent miscarriage

L. Luo, Li, D. H., Wei, S. G., Zhang, H. B., Li, S. B., and Zhao, J., Polymorphisms in the endothelial nitric oxide synthase gene associated with recurrent miscarriage, vol. 12, pp. 3879-3886, 2013.

Endothelial nitric oxide synthase (eNOS) is an enzyme that influences placental human chorionic gonadotropin production during gestation. Previous studies have indicated an association between eNOS activity, implantation, and maintenance of pregnancy, but proposed associations between polymorphisms of the eNOS gene and recurrent miscarriage (RM) are controversial.

Endothelial nitric oxide synthase gene polymorphisms and essential hypertension in Han Chinese

H. G. Wang, Wang, J. L., Chang, P., Cao, F. L., Liu, X. C., Ma, Y. B., Zhai, G. X., and Gao, H. Q., Endothelial nitric oxide synthase gene polymorphisms and essential hypertension in Han Chinese, vol. 9, pp. 1896-1907, 2010.

We examined the effect of polymorphisms in the endothelial nitric oxide synthase gene on the risk for essential hypertension in a Han Chinese population through a meta-analysis of data from 15 studies. Associations between increased risk for essential hypertension and 4b/a were obtained in a dominant model and allele contrast (aa + ab vs bb: odds ratio (OR)FE = 1.26, 95% confidence interval (CI) = 1.10-1.44; a vs b allele: ORFE = 1.23, 95%CI: 1.09-1.40). Four studies with sample sizes over 500 produced similar results.

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