Epidermal growth factor receptor

Relationship of EGFR DNA methylation with the severity of non-small cell lung cancer

J. Li, Jia, X. F., Liu, J., Liu, J. J., and Zhao, H. B., “Relationship of EGFR DNA methylation with the severity of non-small cell lung cancer”, vol. 14, pp. 11915-11923, 2015.

The aim of this study was to study the relationship of EGFR DNA methylation with the severity of non-small-cell lung cancer (NSCLC). We enrolled 54 patients with NSCLC between March 2013 and June 2014 from Department of Cardiothoracic Surgery in our hospital. The methylation levels in the promoter region of the EGFR gene in cancerous and pericarcinomatous tissue were tested by pyrosequencing. EGFR mRNA expression levels were detected by real-time reverse-transcription polymerase chain reaction. The SPSS software was used for data analysis.

Clinical characteristics of patients with non-small cell lung cancers harboring anaplastic lymphoma kinase rearrangements and primary lung adenocarcinoma harboring epidermal growth factor receptor mutations

L. Xu, Lei, J., Wang, Q. Z., Li, J., and Wu, L., “Clinical characteristics of patients with non-small cell lung cancers harboring anaplastic lymphoma kinase rearrangements and primary lung adenocarcinoma harboring epidermal growth factor receptor mutations”, vol. 14, pp. 12973-12983, 2015.

Echinoderm microtubule associated protein like 4-anaplastic lymphoma kinase (EML4-ALK) gene rearrangements and epidermal growth factor receptor (EGFR) mutations in non-small cell lung cancer (NSCLC) have been intensively studied. The objective of this study was to determine the clinicopathological characteristics in genotype-specific subsets of patients with NSCLC to help ensure the optimal identification of patients whose tumors harbor these two driver mutations.