Epidermal growth factor receptor

Effect of atmospheric fine particles on epidermal growth factor receptor mRNA expression in mouse skin tissue

X. Han, Liang, W. L., Zhang, Y., Sun, L. D., Liang, W. Y., Han, X., Liang, W. L., Zhang, Y., Sun, L. D., Liang, W. Y., Han, X., Liang, W. L., Zhang, Y., Sun, L. D., and Liang, W. Y., “Effect of atmospheric fine particles on epidermal growth factor receptor mRNA expression in mouse skin tissue”, vol. 15, p. -, 2016.

We investigated the effect of atmospheric fine particles on epidermal growth factor receptor (Egfr) mRNA expression in mouse skin tissue and explored the effect of atmospheric fine particles on skin aging. Forty female BALB/c mice were randomly divided into four groups (each comprising 10 mice) as follows: a saline control group and low-, medium-, and high-dose atmospheric fine particle groups (1.6, 8.0, and 40.0 mg/kg, respectively) (fine particles were defined as those with a diameter of £2.5 mm, i.e., PM2.5).

Relationship of EGFR DNA methylation with the severity of non-small cell lung cancer

J. Li, Jia, X. F., Liu, J., Liu, J. J., and Zhao, H. B., “Relationship of EGFR DNA methylation with the severity of non-small cell lung cancer”, vol. 14, pp. 11915-11923, 2015.

The aim of this study was to study the relationship of EGFR DNA methylation with the severity of non-small-cell lung cancer (NSCLC). We enrolled 54 patients with NSCLC between March 2013 and June 2014 from Department of Cardiothoracic Surgery in our hospital. The methylation levels in the promoter region of the EGFR gene in cancerous and pericarcinomatous tissue were tested by pyrosequencing. EGFR mRNA expression levels were detected by real-time reverse-transcription polymerase chain reaction. The SPSS software was used for data analysis.

Clinical characteristics of patients with non-small cell lung cancers harboring anaplastic lymphoma kinase rearrangements and primary lung adenocarcinoma harboring epidermal growth factor receptor mutations

L. Xu, Lei, J., Wang, Q. Z., Li, J., and Wu, L., “Clinical characteristics of patients with non-small cell lung cancers harboring anaplastic lymphoma kinase rearrangements and primary lung adenocarcinoma harboring epidermal growth factor receptor mutations”, vol. 14, pp. 12973-12983, 2015.

Echinoderm microtubule associated protein like 4-anaplastic lymphoma kinase (EML4-ALK) gene rearrangements and epidermal growth factor receptor (EGFR) mutations in non-small cell lung cancer (NSCLC) have been intensively studied. The objective of this study was to determine the clinicopathological characteristics in genotype-specific subsets of patients with NSCLC to help ensure the optimal identification of patients whose tumors harbor these two driver mutations.

Expression and prognostic influence of NF-κB and EGFR in esophageal cancer

Y. Q. Zhang, Zhang, J. J., Song, H. J., and Li, D. W., “Expression and prognostic influence of NF-κB and EGFR in esophageal cancer”, vol. 14, pp. 16819-16826, 2015.

The goal of this study was to investigate the expression profiles of nuclear factor-kappa B (NF-κB) and epidermal growth factor receptor (EGFR) in esophageal cancer and to determine their association with tumor prognosis. This study included 40 esophageal cancer patients [22 men and 18 women; average age = 62.7 ± 3.9 years; tumor-node-metastasis (TNM) staging: 12 patients with stage I, 13 patients with stage II, and 15 patients with stage III disease]. Tumor tissues and tumor-adjacent tissue specimens were collected during radical resections at our hospital.

Study of the methylation patterns of the EGFR gene promoter in non-small cell lung cancer

Z. Y. Pan, Jiang, Z. S., and Ouyang, H. Q., “Study of the methylation patterns of the EGFR gene promoter in non-small cell lung cancer”, vol. 14, pp. 9813-9820, 2015.

We investigated the methylation state of the epidermal growth factor receptor (EGFR) gene promoter in non-small cell lung cancer (NSCLC) and analyzed its effect on tumor biology. We enrolled 120 patients with NSCLC who had been confirmed by pathologic diagnosis and had been operated on. The methylation states of the EGFR gene promoter were detected and analyzed and a prognosis was given. NSCLC cell lines and nude mice were used to study the treatment reactivity of gefitinib (an EGFR inhibitor) with or without 5-aza-2'-deoxycytidine (5-aza-CdR) intervention.

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