Epithelial ovarian cancer

Gene expression profiling of epithelial ovarian cancer reveals key genes and pathways associated with chemotherapy resistance

M. Zhang, Luo, S. C., Zhang, M., Luo, S. C., Zhang, M., and Luo, S. C., Gene expression profiling of epithelial ovarian cancer reveals key genes and pathways associated with chemotherapy resistance, vol. 15, p. -, 2016.

The aim of this study is to analyze gene expression data to identify key genes and pathways associated with resistance to platinum-based chemotherapy in epithelial ovarian cancer (EOC) and to improve clinical treatment strategies. The gene expression data set was downloaded from Gene Expression Omnibus and included 12 chemotherapy-resistant EOC samples and 16 chemotherapy-sensitive EOC samples. A differential analysis was performed to screen out differentially expressed genes (DEGs).

Downregulation of microRNA-630 inhibits cell proliferation and invasion and enhances chemosensitivity in human ovarian carcinoma

Y. T. Zou, Gao, J. Y., Wang, H. L., Wang, Y., Wang, H., and Li, P. L., Downregulation of microRNA-630 inhibits cell proliferation and invasion and enhances chemosensitivity in human ovarian carcinoma, vol. 14, pp. 8766-8777, 2015.

MicroRNAs (miRNAs) are a family of small non-coding RNAs (approximately 21-23 nt long) that can target genes for either degradation of mRNA or inhibition of translation. miRNAs have not been comprehensively studied in human epithelial ovarian carcinoma (EOC). MicroRNA-630 (miR-630) has been frequently observed to be aberrantly expressed in various types of tumors. The present study explored the functions of miR-630 in the proliferation, apoptosis, chemosensitivity, and invasion of EOC.

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