ERK1/2 signaling pathway

Involvement of ERK1/2 signaling in proliferation of eight liver cell types during hepatic regeneration in rats

X. G. Chen, Xu, C. S., and Liu, Y. M., Involvement of ERK1/2 signaling in proliferation of eight liver cell types during hepatic regeneration in rats, vol. 12, pp. 665-677, 2013.

It has been well established that ERK1/2 signaling, often subdivided into nine types of pathways, can regulate the hepatocyte proliferative response during liver regeneration. However, the effect of ERK1/2 signaling on the proliferation of other hepatic cell types remains unclear. We isolated and purified 8 liver cell types at 10 time points after 2/3 hepatectomy in adult rats. For each cell type, mRNA expression changes for ERK1/2 signaling-involved genes were monitored up to 168 h, using microarrays. Real-time PCR assays were performed for array data verification.

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